Transposition activity is generally maintained at a low level. An often-cited reason for this is that high activities and the accompanying mutagenic effect of genome rearrangements would be detrimental to the host cell (see [1]). Endogenous transposase promoters, in contrast to those assembled by the juxtaposition of -10 and -35 hexamers in those IS families whose transposition passes through a double-strand circular transposon intermediate, are generally weak and many are partially located in the terminal IRs. This would enable their autoregulation by Tpase binding.
Bibliography
- ↑
Doolittle WF, Kirkwood TB, Dempster MA . Selfish DNAs with self-restraint. - Nature: 1984 Feb 9-15, 307(5951);501-2 [PubMed:6320009]
[DOI]
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| General Information | Overview, IS History, What Is an IS?, ISfinder and the Growing Number of IS, IS Identification, IS Distribution, Major Groups are Defined by the Type of Transposase They Use, Fuzzy Borders, tIS - IS and relatives with passenger genes, IS derivatives of Tn3 family transposons, IS related to Integrative Conjugative Elements (ICEs), IS91 and ISCR, Non-autonomous IS derivatives, Relationship Between IS and Eukaryotic TE, Impact of IS on Genome Evolution - The Importance of Time Scale, Target Choice, Influence of transposition mechanisms on genome impact, IS and Gene Expression, IS Organization, Control of transposition activity, Transposase expression and activity, Reaction mechanisms, The casposases |
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| Insertion Sequences | IS1 family, IS1595 family, IS3 family, IS481 family, IS1202 family, IS4 and related families, IS5 and related IS1182 families, IS6 family, IS21 family, IS30 family, IS66 family, IS110 family, IS256 family, IS630 family, IS982 family, IS1380 family, ISAs1 family, ISL3 family, ISAzo13 family, IS607 family, IS91-ISCR families, IS200-IS605 family |
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| Transposable Elements | |
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