Mobile element type:
Transposon
Name:
Tn6188
Synonyms:
Accession:
Tn6188-HF565366
Family:
Tn554
Group:
First isolate:
Yes
Partial:
ND
Evidence of transposition:
Yes
Host Organism:
Listeria monocytogenes 6179
Date of Isolation:
2013
Country:
Austria
Molecular Source:
chromosome
ORF Summary
| Name | Associated TE | Coordinates | Orientation | Class | Subclass |
|---|---|---|---|---|---|
| tnpA | Tn6188 | 132-1217 | + | Transposase | |
| tnpB | Tn6188 | 1220-3133 | + | Transposase | |
| tnpC | Tn6188 | 3135-3500 | + | Accessory Gene | Helper |
| qacH (ARO:3003836) | Tn6188 | 3764-4135 | - | Passenger Gene | Antibiotic Resistance |
| AUH55373.1 | Tn6188 | 4138-4656 | - | Passenger Gene | Hypothetical |
ORF Details
| Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | tnpA | TnpA | Tn6188 | 361 | 132-1217 | + |
|---|
| Class: | Transposase | ||||||||||
| Protein Sequence: | MKVQKVIVEE KPYPLYILLD KEFEVIEPVK RFIKYLDNTG KAPNTIKTYC YHLKLFYEFM SQRGIGLEDL KFEEMSNFVG WLRNPTGDVK VITLQPKKAK REETSVNAIL NAITSFLEYL NRTEDFKAID MTKEARGRNF KGFLHHISKG KSYKKNILKL RVKKKLVQVL EHEQVKAIID ACHTKRDKLL IMLMYEGGLR IGEVLSLRIE DISTWDNLIN ITPRDHNENG AYIKLRKERT IDVSKELMAL YTDYLVHEYG EDLEHDYIFI NLKESYFGKP LKYQSVLDLI RRLGKRTGIT FTAHMLRHTH ATELIRSGWD AAYVQKRLGH AHVQTTLDTY VHLSDQDMKN EYKAYLQGRE T |
||||||||||
| Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | tnpB | TnpB | Tn6188 | 637 | 1220-3133 | + |
|---|
| Class: | Transposase | ||||||||||
| Protein Sequence: | MKFPSVATNR KLVTSTEINK KISDMTSVLQ GFWAADRWDI RICPHPSAIE LSKNPSLKNR WVNFDKVENI WLKTELKYFY YVHLNNGTWN AKSVWIRKGT VISRMLGFLN LNYPDITSIT EVPIKKALSE YRTYLAEQGI RTTTTNYKLD INQKKIPVYA NSYYVTNLKQ FMEFYEDFYF DGDEWEKDVW NRRKLSLSED KVNPTSYEYT INFKGFENDY FKELVKRYCK LMLNTRSFSH VVDTASRLKE FFNFINKNCK GIRRIHQLTR NEVEQYFNYI NLKGLKSSTV TGRISTLDVF FTTIQRYDWK DTPSKILIFQ EDYPKVPKAL PRYIDEHILE QLNGKLDKLE PYIATMIMVL QECGMRISEL CTLKKGSVIT DKEGDCFLKY YQWKMKKEHI IPISKEIAAL ILVQEQRVAD ELDDGCVYVF PRKDGSPLKQ DTFRVKLNEL AYEEKITDSK GEIFRFHAHA FRHTVGTRMI NNGVPQHIVQ KFLGHESPEM TARYAHIFDE TLKKEFTKFK ETLVTNNGNI LDLSEENTEA DNTDLQWFKK NINAQALPNG YCRLPVIAGP CPHANACLDC TNFCTSKQFL NEHEDHLKRT KEVLNRAKQN QWQRQVETNE RVKIRLEQII HSLKETN |
||||||||||
| Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | tnpC | TnpC | Tn6188 | 121 | 3135-3500 | + |
|---|
| Class: | Accessory Gene | ||||||||||
| Subclass: | Helper | ||||||||||
| Sequence Family: | Tn554_family | ||||||||||
| Comment: | target specificity and orientation | ||||||||||
| Protein Sequence: | MTRRSNTTAI IQLSKEKSEN TRIRVEKTIS EMALKKERIN FNSVAQKANV SKSWLYKQKG IRTRVETLRG MQISGVVPRK PSKSPRSEDV LIKTLKSRIK ALEEENEQLK DQVQKLHGKL F |
||||||||||
| Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | qacH (ARO:3003836) | QacH | Tn6188 | 123 | 3764-4135 | - |
|---|
| Class: | Passenger Gene | ||||||||||
| Subclass: | Antibiotic Resistance | ||||||||||
| Function: | antibiotic efflux (ARO:0010000) | ||||||||||
| Sequence Family: | small multidrug resistance (SMR) antibiotic efflux pump (ARO:0010003) | ||||||||||
| Target: | quaternary ammonium salts | ||||||||||
| Comment: | subunit of the qac multidrug efflux pump||loose match to reference sequence for ARO:3003836 (bitscore:117) | ||||||||||
| Protein Sequence: | MSYLYLALAI VGEIIGSSLL KASEGFSKLF PTIGVIIAFV VSFFFLSLSL KTIPLNTAYS LWSGLGLVLT TIISVLIWKE KLNMASIAGI TLILAGVVIL NLFGPGHGEP DHKASETITI NEE |
||||||||||
| Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | AUH55373.1 | AUH55373.1 | Tn6188 | 172 | 4138-4656 | - |
|---|
| Class: | Passenger Gene | ||||||||||
| Subclass: | Hypothetical | ||||||||||
| Comment: | tetR family trancription regulator | ||||||||||
| Protein Sequence: | MTAASEIVKE EGVVKLTLEA VAQRAGVSKG GLLYHYPSKE ALIKGMVEDW TNNFFESIKT LVNKDSKETG KWNRAYINTT LFDLDNNNNK NLSSALMAAM FINPDLLDDY KQKYDILHTK LLNDGIDPLK ITMARLLIDG LWFSEIFEIA PLNEEVKKQI FDELIMMIQE GE |
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1. Muller A, Rychli K, Muhterem-Uyar M, Zaiser A, Stessl B, Guinane CM, Cotter PD, Wagner M, Schmitz-Esser S.
Tn6188 - a novel transposon in Listeria monocytogenes responsible for tolerance to benzalkonium chloride.. PLoS One. 2013 Oct 2;8(10):e76835. doi: 10.1371/journal.pone.0076835. eCollection 2013. PubMed ID:
24098567
.