Mobile element type:  Transposon
Name:  Tn2411
Synonyms: 
Accession:  Tn2411-FN554766
Family:  Tn3
Group:  Tn21
First isolate:  Yes
Partial:  ND
Evidence of transposition:  ND

Host Organism:  Escherichia coli 042
Date of Isolation:  2010
Country: 
Molecular Source:  chromosome

Name Coordinates Direction Length Sequence
IRL 1-37 + 37 GGGGCACCTC AGAAAACGGA AAATAAAGCA CGCTAAG
repeat i4 9-27 + 19 TCAGAAAACG GAAAATAAA
IRR 18015-18055 - 41 GGGGTCGTCT CAGAAAACGG AAAATAAAGC ACGCTAAGCC G
repeat i4 18028-18046 - 19 TCAGAAAACG GAAAATAAA

Name Associated TE Coordinates Orientation Length Sequence
attC aadA1a core In_Tn4 11806-11859 + 54 CGCTTGAGTT AAGCCGCGCC GCGAAGCGGC GTCGGCTTGA ACGAATTGTT AGAC
attI In_Tn4 12662-12717 + 56 CTTTGTTTTA GGGCGACTGC CCTGCTGCGT AACATCGTTG CTGCTCCATA ACATCA
res Tn2411 14352-14482 + 131 GCCGCCGTCA GGTTGAGGCA TACCCTAACC TGATGTCAGA TGCCATGTGT AAATTGCGTC AGGATAGGAT TGAATTTTGA ATTTATTGAC ATATCTCGTT GAAGGTCATA GAGTCTTCCC TGACATTTTG C
res_site_I Tn2411 14352-14390 + 39 GCCGCCGTCA GGTTGAGGCA TACCCTAACC TGATGTCAG
res_site_II Tn2411 14404-14447 + 44 ATTGCGTCAG GATAGGATTG AATTTTGAAT TTATTGACAT ATCT
res_site_III Tn2411 14451-14482 + 32 TGAAGGTCAT AGAGTCTTCC CTGACATTTT GC

ORF Summary
Name Associated TE Coordinates Orientation Class Subclass
merR Tn2411 33-467 - Passenger Gene Heavy Metal Resistance
merT Tn2411 539-889 + Passenger Gene Heavy Metal Resistance
merP Tn2411 903-1178 + Passenger Gene Heavy Metal Resistance
merC Tn2411 1214-1636 + Passenger Gene Heavy Metal Resistance
merA Tn2411 1688-3382 + Passenger Gene Heavy Metal Resistance
merD Tn2411 3400-3762 + Passenger Gene Heavy Metal Resistance
merE Tn2411 3759-3995 + Passenger Gene Heavy Metal Resistance
urfM 5'-end Tn2411 3992-4662 + Passenger Gene Other
tniA In_Tn4 4774-6453 + Transposase
tniB delta1 In_Tn4 6456-7316 + Accessory Gene
istA IS1326 7418-8941 + Transposase None
istB IS1326 8928-9713 + Accessory Gene ATPase Transposition Helper
GNAT_fam In_Tn4 9889-10389 - Passenger Gene Antibiotic Resistance
qacEdelta1 (ARO:3005010) In_Tn4 11350-11697 - Passenger Gene Antibiotic Resistance
aadA (ARO:3002601) In_Tn4 11861-12652 - Passenger Gene Antibiotic Resistance
intI1 In_Tn4 12801-13814 + Integron Integrase Class 1
tnpM Tn2411 14017-14367 + Accessory Gene Inhibitor
tnpR Tn2411 14493-15053 + Accessory Gene Resolvase
ORF Details
Gene Name Protein Name Associated TE Gene Length Coordinates Strand
merR MerR Tn2411 144 33-467 -
Class: Passenger Gene
Subclass: Heavy Metal Resistance
Function: activator-repressor of mer operon
Target: Mercury
Protein Sequence: MENNLENLTI GVFAKAAGVN VETIRFYQRK GLLREPDKPY GSIRRYGEAD VVRVKFVKSA QRLGFSLDEI AELLRLDDGT HCEEASSLAE HKLKDVREKM ADLARMETVL SELVCACHAR KGNVSCPLIA SLQGEAGLAR SAMP

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
merT MerT Tn2411 116 539-889 +
Class: Passenger Gene
Subclass: Heavy Metal Resistance
Function: cytosolic mercuric ion transport protein
Target: Mercury
Protein Sequence: MSEPQNGRGA LFAGGLAAIL ASTCCLGPLV LVALGFSGAW IGNLTVLEPY RPLFIGAALV ALFFAWKRIY RPVQACKPGE VCAIPQVRAT YKLIFWIVAV LVLVALGFPY VVPFFY

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
merP MerP Tn2411 91 903-1178 +
Class: Passenger Gene
Subclass: Heavy Metal Resistance
Function: mercury transport
Target: Mercury
Protein Sequence: MKKLFASLAL AAAVAPVWAA TQTVTLAVPG MTCAACPITV KKALSKVEGV SKVDVGFEKR EAVVTFDDTK ASVQKLTKAT ADAGYPSSVK Q

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
merC MerC Tn2411 140 1214-1636 +
Class: Passenger Gene
Subclass: Heavy Metal Resistance
Function: transmembrane protein mercury transport
Target: Mercury
Protein Sequence: MGLMTRIADK TGALGSVVSA MGCAACFPAL ASFGAAIGLG FLSQYEGLFI SRLLPLFAAL AFLANALGWF SHRQWLRSLL GMIGPAIVFA ATVWLLGNWW TANLMYVGLA LMIGVSIWDF VSPAHRRCGP DGCELPAKRL

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
merA MerA Tn2411 564 1688-3382 +
Class: Passenger Gene
Subclass: Heavy Metal Resistance
Function: mercuric ion reductase
Target: Mercury
Protein Sequence: MSTLKITGMT CDSCAVHVKD ALEKVPGVQS ADVSYAKGSA KLAIEVGTSP DALTAAVAGL GYRATLADAP SVSTPGGLLD KMRDLLGRND KTGSSGALHI AVIGSGGAAM AAALKAVEQG ARVTLIERGT IGGTCVNVGC VPSKIMIRAA HIAHLRRESP FDGGIAATTP TIQRTALLAQ QQARVDELRH AKYEGILEGN PAITVLHGSA RFKDNRNLIV QLNDGGERVV AFDRCLIATG ASPAVPPIPG LKDTPYWTST EALVSETIPK RLAVIGSSVV ALELAQAFAR LGAKVTILAR STLFFREDPA IGEAVTAAFR MEGIEVREHT QASQVAYING EGDGEFVLTT AHGELRADKL LVATGRAPNT RKLALDATGV TLTPQGAIVI DPGMRTSVEH IYAAGDCTDQ PQFVYVAAAA GTRAAINMTG GDAALNLTAM PAVVFTDPQV ATVGYSEAEA HHDGIKTDSR TLTLDNVPRA LANFDTRGFI KLVVEEGSGR LIGVQAVAPE AGELIQTAAL AIRNRMTVQE LADQLFPYLT MVEGLKLAAQ TFNKDVKQLS CCAG

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
merD MerD Tn2411 120 3400-3762 +
Class: Passenger Gene
Subclass: Heavy Metal Resistance
Function: secondary regulatory protein
Target: Mercury
Protein Sequence: MSAYTVSQLA HNAGVSVHIV RDYLVRGLLR PVACTTGGYG VFDDAALQRL CFVRAAFEAG IGLDALARLC RALDAADGAQ AAAQLAVLRQ LVERRRAALA HLDAQLASMP AERAHEEALP

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
merE MerE Tn2411 78 3759-3995 +
Class: Passenger Gene
Subclass: Heavy Metal Resistance
Function: mercury transport
Target: Mercury
Comment: similar to urf-1 in pKLH2 (GenBank AF213017), pKLH272 (Genbank Y08992), pMER610 (GenBank Y08993), pKLH210 (GenBank Y10102), Tn5036 (Genbank Y09025), orf1 in Tn501 (GenBank Z00027), and urf-1 in Tn5041 (GenBank X98999)
Protein Sequence: MNAPDKLPPE TRQPVSGYLW GALAVLTCPC HLPILAAVLA GTTAGAFLGE HWGVAALALT GLFVLAVTRL LRAFRGGS

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
urfM 5'-end N/A Tn2411 223 3992-4662 +
Class: Passenger Gene
Subclass: Other
Comment: urfMORF interrupted by insertion of In2
Protein Sequence: MTSSQPAGWT AAELAQAAAR GQLDLHYQPL VDLRDHRIAG AEALMRWRHP RLGLLPPGQF LPLAESFGLM PEIGAWVLGE ACRQMHKWQG PAWQPFRLAI NVSASQVGPT FDDEVKRVLA DMALPAELLE IELTESVAFG NPALFASFDA LRAIGVRFAA DDFGTGYSCL QHLKCCPITT LKIDQSFVAR LPDDARDQTI VRAVIQLAHG LGMDVIFRRR LHQ

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
tniA TniA In_Tn4 559 4774-6453 +
Class: Transposase
Transposase Chemistry: DDE
Comment: can be extended upstream by 12 amino acids| identical to tniA (Tn1721 and In2)| 25% amino acid sequence identity to TnsB from Tn7
Protein Sequence: MATDTPRIPE QGVATLPDEA WERARRRAEI ISPLAQSETV GHEAADMAAQ ALGLSRRQVY VLIRRARQGS GLVTDLVPGQ SGGGKGKGRL PEPVERVIHE LLQKRFLTKQ KRSLAAFHRE VTQVCKAQKL RVPARNTVAL RIASLDPRKV IRRREGQDAA RDLQGVGGEP PAVTAPLEQV QIDHTVIDLI VVDDRDRQPI GRPYLTLAID VFTRCVLGMV VTLEAPSAVS VGLCLVHVAC DKRPWLEGLN VEMDWQMSGK PLLLYLDNAA EFKSEALRRG CEQHGIRLDY RPLGQPHYGG IVERIIGTAM QMIHDELPGT TFSNPDQRGD YDSENKAALT LRELERWLTL AVGTYHGSVH NGLLQPPAAR WAEAVARVGV PAVVTRATSF LVDFLPILRR TLTRTGFVID HIHYYADALK PWIARRERWP SFLIRRDPRD ISRIWVLEPE GQHYLEIPYR TLSHPAVTLW EQRQALAKLR QQGREQVDES ALFRMIGQMR EIVTSAQKAT RKARRDADRR QHLKTSARPD KPVPPDTDIA DPQADNLPPA KPFDQIEEW

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
tniB delta1 TniB delta1 In_Tn4 286 6456-7316 +
Class: Accessory Gene
Function: probable ATP-binding protein.
Comment: probably truncated by insertion of IS1326::IS1353
Protein Sequence: MDEYPIIDLS HLLPAAQGLA RLPADERIQR LRADRWIGYP RAVEALNRLE ALYAWPNKQR MPNLLLVGPT NNGKSMIVEK FRRTHPASSD ADQEHIPVLV VQMPSEPSVI RFYVALLAAM GAPLRPRPRL PEMEQLALAL LRKVGVRMLV IDELHNVLAG NSVNRREFLN LLRFLGNELR IPLVGVGTRD AYLAIRSDDQ LENRFEPMML PVWEANDDCC SLLASFAASL PLRRPSPIAT LDMARYLLTR SEGTIGELAH LLMAAAIVAV ESGEEAINHR TLSMAC

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
istA IstA IS1326 507 7418-8941 +
Class: Transposase
Transposase Chemistry: DDE
Protein Sequence: MINVAILSAI RRWHFRDGAS IREIARRSGL SRNTVRKYLQ SKVVEPQYPA RDSVGKLSPF EPKLRQWLST EHKKTKKLRR NLRSMYRDLV ALGFTGSYDR VCAFARQWKD SEQFKAQTSG KGCFIPLRFA CGEAFQFDWS EDFARIAGKQ VKLQIAQFKL AHSRAFVLRA YYQQKHEMLF DAHWHAFQIF GGIPKRGIYD NMKTAVDSVG RGKERRVNQR FTAMVSHYLF DAQFCNPASG WEKGQIEKNV QDSRQRLWQG APDFQSLADL NVWLEHRCKA LWSELRHPEL DQTVQEAFAD EQGELMALPN AFDAFVEQTK RVTSTCLVHH EGNRYSVPAS YANRAISLRI YADKLVMAAE GQHIAEHPRL FGSGHARRGH TQYDWHHYLS VLQKKPGALR NGAPFAELPP AFKKLQSILL QRPGGDRDMV EILALVLHHD EGAVLSAVEL ALECGKPSKE HVLNLLGRLT EEPPPKPIPI PKGLRLTLEP QANVNRYDSL RRAHDAA

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
istB IstB IS1326 261 8928-9713 +
Class: Accessory Gene
Subclass: ATPase Transposition Helper
Function: stimulates transposition
Protein Sequence: MMQHEGHVRI LKSLKLFGMA HAIEELGNQN SPAFNQALPM LDSLIKAEVA EREVRSVNYQ LRVAKFPVYR DLVGFDFSQS LVNEATVKQL HRCDFMEQAQ NVVLIGGPGT GKTHLATAIG TQAVMHLNRR VRFFSTVDLV NALEQEKSSG RQGQIANRLL YADLVILDEL GYLPFSQTGG ALLFHLLSKL YEKTSVILTT NLSFSEWSRV FGDEKMTTAL LDRLTHHCHI LETGNESYRF KHSSTQNKQE EKQTRKLKIE T

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
GNAT_fam GNAT_fam In_Tn4 166 9889-10389 -
Class: Passenger Gene
Subclass: Antibiotic Resistance
Sequence Family: Acetyltransf_1 (Pfam:PF00583)
Target: aminoglycoside antibiotic (ARO:0000016)
Comment: putative acetyltransferase ADU64769.1
Protein Sequence: MDSEEPPNVR VACSGDIDEV VRLMHDAAAW MSAKGTPAWD VARIDRTFAE TFVLRSELLV ASCSDGIVGC CTLSAEDPEF WPDALKGEAA YLHKLAVRRT HAGRGVSSAL IEACRHAART QGCAKLRLDC HPNLRGLYER LGFTHVDTFN PGWDPTFIAE RLELEI

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
qacEdelta1 (ARO:3005010) QacEdelta1 In_Tn4 115 11350-11697 -
Class: Passenger Gene
Subclass: Antibiotic Resistance
Function: antibiotic efflux (ARO:0010000)
Sequence Family: major facilitator superfamily (MFS) antibiotic efflux pump (ARO:0010002)
Target: disinfecting agents and antiseptics(ARO:3005386)
Comment: subunit of the qac multidrug efflux pump||perfect match to reference sequence for ARO:3005010 (bitscore:219)
Protein Sequence: MKGWLFLVIA IVGEVIATSA LKSSEGFTKL APSAVVIIGY GIAFYFLSLV LKSIPVGVAY AVWSGLGVVI ITAIAWLLHG QKLDAWGFVG MGLIIAAFLL ARSPSWKSLR RPTPW

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
aadA (ARO:3002601) AadA In_Tn4 263 11861-12652 -
Class: Passenger Gene
Subclass: Antibiotic Resistance
Function: antibiotic inactivation (ARO:0001004)
Sequence Family: ANT(3'')(ARO:3004275)
Transposase Chemistry: aminoglycoside nucleotidyltransferase
Target: aminoglycoside antibiotic (ARO:0000016)
Comment: perfect match to reference sequence for ARO:3002601||Synonyms: aadA1-pm, aadA, aadA1, aad(3'')(9)
Protein Sequence: MREAVIAEVS TQLSEVVGVI ERHLEPTLLA VHLYGSAVDG GLKPHSDIDL LVTVTVRLDE TTRRALINDL LETSASPGES EILRAVEVTI VVHDDIIPWR YPAKRELQFG EWQRNDILAG IFEPATIDID LAILLTKARE HSVALVGPAA EELFDPVPEQ DLFEALNETL TLWNSPPDWA GDERNVVLTL SRIWYSAVTG KIAPKDVAAD WAMERLPAQY QPVILEARQA YLGQEEDRLA SRADQLEEFV HYVKGEITKV VGK

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
intI1 IntI1 In_Tn4 337 12801-13814 +
Class: Integron Integrase
Subclass: Class 1
Sequence Family: Class 1 Integron Tyrosine Integrase
Transposase Chemistry: Tyrosine
Protein Sequence: MKTATAPLPP LRSVKVLDQL RERIRYLHYS LRTEQAYVHW VRAFIRFHGV RHPATLGSSE VEAFLSWLAN ERKVSVSTHR QALAALLFFY GKVLCTDLPW LQEIGRPRPS RRLPVVLTPD EVVRILGFLE GEHRLFAQLL YGTGMRISEG LQLRVKDLDF DHGTIIVREG KGSKDRALML PESLAPSLRE QLSRARAWWL KDQAEGRSGV ALPDALERKY PRAGHSWPWF WVFAQHTHST DPRSGVVRRH HMYDQTFQRA FKRAVEQAGI TKPATPHTLR HSFATALLRS GYDIRTVQDL LGHSDVSTTM IYTHVLKVGG AGVRSPLDAL PPLTSER

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
tnpM TnpM Tn2411 116 14017-14367 +
Class: Accessory Gene
Subclass: Inhibitor
Function: transposition regulator||reported to enhance Tn21 transposition and suppress resolution of cointegrate replicons in vivo
Comment: 3'-end of urfM ORF, which is interrupted by insertion of In2||inhibits tranposition probably by inhibiting resolution
Protein Sequence: MEVVAEGVET PDCLAWLRQA GCDTVQGFLF ARPMPAAAFV GFVNQWRNTT MNANEPSTSC CVCCKEIPLD AAFTPEGAEY VEHFCGLECY QRFQARASTA TETSVKPDAC DSPPSG

Gene Name Protein Name Associated TE Gene Length Coordinates Strand
tnpR TnpR Tn2411 186 14493-15053 +
Class: Accessory Gene
Subclass: Resolvase
Function: resolvase||serine site-specific recombinase
Sequence Family: Serine Site-Specific Recombinase
Transposase Chemistry: Serine
Comment: identical to tnpR (TnAs3 )
Protein Sequence: MTGQRIGYIR VSTFDQNPER QLEGVKVDRA FSDKASGKDV KRPQLEALIS FARTGDTVVV HSMDRLARNL DDLRRIVQTL TQRGVHIEFV KEHLSFTGED SPMANLMLSV MGAFAEFERA LIRERQREGI ALAKQRGAYR GRKKSLSSER IAELRQRVEA GEQKTKLARE FGISRETLYQ YLRTDQ

TnCentral Accession TE Name Type Coordinates Strand Length
In_Tn4-KY749247.1 In_Tn4 integron 4633-14016 + 9384
IS1326-KY749247.1 IS1326 insertion sequence 7311-9780 + 2470

Name Associated TE Coordinates Direction Length Sequence
IRt In_Tn4 4633-4665 + 33 TGTCATTTTC AGAAGACGAC TGCACCAGTT GAT
repeat t1 In_Tn4 4641-4659 + 19 TCAGAAGACG ACTGCACCA
repeat t2 In_Tn4 4681-4699 - 19 TCAGGAGCTG GCTGCACAA
repeat t3 In_Tn4 4710-4729 + 20 TCAGAAGTGA TCTGCACCAA
repeat t4 In_Tn4 4742-4760 + 19 TCAATACTCG TGTGCACCA
IRR IS1326 9755-9780 - 26 TGTTGATTTG CACCCAAATT TGACCC
repeat i4 In_Tn4 13897-13915 - 19 TCAGCGGACG CAGGGAGGA
repeat i3 In_Tn4 13925-13943 - 19 TCAGGCAACG ACGGGCTGC
repeat i2 In_Tn4 13967-13985 - 19 TCAGAAGCCG ACTGCACTA
IRi In_Tn4 13984-14016 - 33 TGTCGTTTTC AGAAGACGGC TGCACTGAAC GTC
repeat i1 In_Tn4 13990-14008 - 19 TCAGAAGACG GCTGCACTG

1.  Chaudhuri RR, Sebaihia M, Hobman JL, Webber MA, Leyton DL, Goldberg MD, Cunningham AF, Scott-Tucker A, Ferguson PR, Thomas CM, Frankel G, Tang CM, Dudley EG, Roberts IS, Rasko DA, Pallen MJ, Parkhill J, Nataro JP, Thomson NR, Henderson IR.  Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042..  PLoS One. 2010 Jan 20;5(1):e8801. doi: 10.1371/journal.pone.0008801.  PubMed ID: 20098708 .