Mobile element type:
Transposon
Name:
Tn1721
Synonyms:
Accession:
Tn1721-X61367.1
Family:
Tn3
Group:
Tn21
First isolate:
Yes
Partial:
ND
Evidence of transposition:
Yes
Host Organism:
Escherichia coli
Date of Isolation:
1979
Country:
Molecular Source:
plasmid pRSD1
Name | Coordinates | Direction | Length | Sequence |
---|---|---|---|---|
IRL | 1-38 | + | 38 | GGGGGAACCG CAGAATTCGG AAAAAATCGT ACGCTAAG |
IRint | 5603-5640 | - | 38 | GGGGAGCCCG CAGAATTCGG AAAAAATCGT CAGCTAAG |
IRR | 11102-11139 | - | 38 | GGGGAGCCCG CAGAATTCGG AAAAAATCGT CAGCTAAG |
Name | Associated TE | Coordinates | Orientation | Length | Sequence |
---|---|---|---|---|---|
res | Tn1721 | 1886-2014 | + | 129 | GCGCATGTCA ATCTAGGCTA TACCCTAACT TGATGTCAGG CAGGGCCGCG CCGCTTCGTC AGAATAGAGT CTGCTTTCCC ATTTTTTGAC ACATGCCCGC GAAGGTTATA GATTTCAGCC TGACAGAAA |
res_site_I | Tn1721 | 1886-1925 | + | 40 | GCGCATGTCA ATCTAGGCTA TACCCTAACT TGATGTCAGG |
res_site_II | Tn1721 | 1938-1981 | + | 44 | GCTTCGTCAG AATAGAGTCT GCTTTCCCAT TTTTTGACAC ATGC |
res_site_III | Tn1721 | 1985-2015 | + | 31 | CGAAGGTTAT AGATTTCAGC CTGACAGAAA T |
ORF Summary
Name | Associated TE | Coordinates | Orientation | Class | Subclass |
---|---|---|---|---|---|
mcp | Tn1721 | 190-1767 | - | Passenger Gene | Other |
tnpR | Tn1721 | 2077-2637 | + | Accessory Gene | Resolvase |
tnpA | Tn1721 | 2641-5607 | + | Transposase | |
tetR (ARO:3003479) | Tn1721 | 5938-6615 | - | Passenger Gene | Antibiotic Resistance |
tet(A) (ARO:3000165) | Tn1721 | 6694-7893 | + | Passenger Gene | Antibiotic Resistance |
yedA | Tn1721 | 7925-8515 | - | Passenger Gene | Other |
tnpA C-ter | Tn1721 | 9354-11106 | + | Transposase |
ORF Details
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | mcp | Mcp | Tn1721 | 525 | 190-1767 | - |
---|
Class: | Passenger Gene | ||||||||||
Subclass: | Other | ||||||||||
Comment: | methyl-accepting chemotaxis protein | ||||||||||
Protein Sequence: | MRQNLPVTGR NLELPKDANI LSTTSPQSHI TYVNPDFIKI SGFTEEELLG QPHNIVRHPD MPPAAFEHMW STLKSGRSWM GLVKNRCKNG DHYWVSAYVT PIAKNGSIVE YQSVRTKPEP EQVLAAEKLY AQLRSGKAAR PKLAASFSVK ILLLIWGSII SSAMAAGMLT DTSISSLLLA TLMSGSLSSV SVLAILSPLG RLVERARNIS NNPLSQSLYT GRTDEFGQIE FALRMMQAET GAIVGRIGDA SNRLSEHTRG LLKDIESSNV LTVEQQAETD QIATAVNQMV ASIQEVASNA QHAADAAGRA DTETASGQRL VAHTSQSITA LEGEIRQATQ VIHELEGQSN EISKVLDVIR GIAEQTNLLA LNAAIEAARA GEQGRGFAVV ADEVRSLAAR TQQSTTDIQS MISALQERAQ SAVTVMEQSS RQAHTSVAHA EEAATALDGI GQRVNEITDM NAQIATAVEQ QGAVSEDINR SIINIRDAAD TNVQTGQNNL QSAKSVAQLT SALSELAKQF WEKRG |
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | tnpR | TnpR | Tn1721 | 186 | 2077-2637 | + |
---|
Class: | Accessory Gene | ||||||||||
Subclass: | Resolvase | ||||||||||
Sequence Family: | Serine Site-Specific Recombinase | ||||||||||
Transposase Chemistry: | Serine | ||||||||||
Protein Sequence: | MQGHRIGYVR VSSFDQNPER QLEQTQVSKV FTDKASGKDT QRPQLEALLS FVREGDTVVV HSMDRLARNL DDLRRLVQKL TQRGVRIEFL KEGLVFTGED SPMANLMLSV MGAFAEFERA LIRERQREGI ALAKQRGAYR GRKKALSDEQ AATLRQRATA GEPKAQLARE FNISRETLYQ YLRTDD |
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | tnpA | TnpA | Tn1721 | 988 | 2641-5607 | + |
---|
Class: | Transposase | ||||||||||
Transposase Chemistry: | DDE | ||||||||||
Protein Sequence: | MPRRLILSAT ERDTLLALPE SQDDLIRYYT FNDSDLSLIR QRRGDANRLG FAVQLCLLRY PGYALGTDSE LPEPVILWVA KQVQAEPASW AKYGERDVTR REHAQELRTY LQLAPFGLSD LPALVRELTE LAQQTDNGLL LAGQALESLR QKRPILPALS VIDRACSEAI ARANRRVYRA LVEPLTDSHR AKLDELLKLK AGSSITWLTW LRQAPLKPNS RHMLEHIERL KTFQLVDLPE GLGRHIHQNR LLKLAREGGQ MTPKDLGKFE PQRRYATLAA VVLESTATVI DELVDLHDRI LVKLFSGAKH KHQQQFQKQG KAMNDKVRLY SRIGQALLEA KESGSDPYAA IEAVIPWDEF TESVSEAELL ARPEGFDHLH LVGENFATLR RYTPALLEVL EPRAAPAAQG VLAAVQTLRE MNADNLRKVP ADAPTAFIKP RWKPLVITPE GLDRKFYEIC ALSELKNALR SGDIWVKGSR QFRDFDDYLL PAEKFAALKR EQALPLAINP NSDQYLEERL QLLDEQLATV TRLAKDNELP DAILTESGLK ITPLDAAVPD RAQALIDQTS QLLPRIKITE LLMDVDDWTG FSRHFTHLKD GAEAKDRTLL LSAILGDAIN LGLTKMAESS PGLTYAKLSW LQAWHIRDET YSAALAELVN HQYRHAFAAH WGDGTTSSSD GQRFRAGGRG ESTGHVNPKY GSEPGRLFYT HISDQYAPFS TRVVNVGVRD STYVLDGLLY HESDLRIEEH YTDTAGFTDH VFALMHLLGF RFAPRIRDLG ETKLYVPQGV QAYPTLRPLI GGTLNIKHVR AHWDDILRLA SSIKQGTVTA SLMLRKFGSY PRQNGLAVAL RELGRIERTL FILDWLQSVE LRRRVHAGLN KGEARNSLAR AVFFNRLGEI RDRSFEQQRY RASGLNLVTA AIVLWNTVYL ERATQGLVEA GKPVDGELLQ FLSPLGWEHI NLTGDYVWRQ SRRLEDGKFR PLRMPGKP |
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | tetR (ARO:3003479) | TetR | Tn1721 | 225 | 5938-6615 | - |
---|
Class: | Passenger Gene | ||||||||||
Subclass: | Antibiotic Resistance | ||||||||||
Function: | antibiotic efflux (ARO:0010000)||antibiotic target alteration (ARO:0001001) | ||||||||||
Sequence Family: | major facilitator superfamily (MFS) antibiotic efflux pump (ARO:0010002) | ||||||||||
Target: | tetracycline antibiotic (ARO:3000050) | ||||||||||
Comment: | 52% match to reference sequence for ARO:3003479 (bitscore: 214)|| repressor of tetA||Synonyms: | ||||||||||
Protein Sequence: | MFISDKVSSM TKLQPNTVIR AALDLLNEVG VDGLTTRKLA ERLGVQQPAL YWHFRNKRAL LDALAEAMLA ENHTHSVPRA DDDWRSFLIG NARSFRQALL AYRDGARIHA GTRPGAPQME TADAQLRFLC EAGFSAGDAV NALMTISYFT VGAVLEEQAG DSDAGERGGT VEQAPLSPLL RAAIDAFDEA GPDAAFEQGL AVIVDGLAKR RLVVRNVEGP RKGDD |
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | tet(A) (ARO:3000165) | Tet(A) | Tn1721 | 399 | 6694-7893 | + |
---|
Class: | Passenger Gene | ||||||||||
Subclass: | Antibiotic Resistance | ||||||||||
Function: | antibiotic efflux (ARO:0010000) | ||||||||||
Sequence Family: | major facilitator superfamily (MFS) antibiotic efflux pump (ARO:0010002) | ||||||||||
Target: | tetracycline antibiotic (ARO:3000050) | ||||||||||
Protein Sequence: | MKPNRPLIVI LSTVALDAVG IGLIMPVLPG LLRDLVHSND VTAHYGILLA LYALMQFACA PVLGALSDRF GRRPVLLVSL AGAAVDYAIM ATAPFLWVLY IGRIVAGITG ATGAVAGAYI ADITDGDERA RHFGFMSACF GFGMVAGPVL GGLMGGFSPH APFFAAAALN GLNFLTGCFL LPESHKGERR PLRREALNPL ASFRWARGMT VVAALMAVFF IMQLVGQVPA ALWVIFGEDR FHWDATTIGI SLAAFGILHS LAQAMITGPV AARLGERRAL MLGMIADGTG YILLAFATRG WMAFPIMVLL ASGGIGMPAL QAMLSRQVDE ERQGQLQGSL AALTSLTSIV GPLLFTAIYA ASITTWNGWA WIAGAALYLL CLPALRRGLW SGAGQRADR |
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | yedA | YedA | Tn1721 | 196 | 7925-8515 | - |
---|
Class: | Passenger Gene | ||||||||||
Subclass: | Other | ||||||||||
Comment: | Eam family inner membranetransporter | ||||||||||
Protein Sequence: | MVVFISAALL GSPIRLMAVL GAICGTAGVA LLVLTPNAAL DPVGVAAGLA GAVSMAFGTV LTRKWQPPVP LLTFTAWQLA AGGLLLVPVA LVFDPPIPMP TGTNVLGLAW LGLIGAGLTY FLWFRGISRL EPTVVSLLGF LSPGTAVAAL LLGWLFLDQT LSALQIIGVL LVIGSIWLGQ RSNRTPRARI ACRKSP |
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | tnpA C-ter | TnpA C-ter | Tn1721 | 584 | 9354-11106 | + |
---|
Class: | Transposase | ||||||||||
Transposase Chemistry: | DDE | ||||||||||
Comment: | truncated tnpA | ||||||||||
Protein Sequence: | AAQGVLAAVQ TLREMNADNL RKVPADAPTA FIKPRWKPLV ITPEGLDRKF YEICALSELK NALRSGDIWV KGSRQFRDFD DYLLPAREGS PARQARAGPA PGDQPEQRPV PGRAFAAAGR AVGHRHPPGQ GQRAARCHPH RVRAENHPAG CGGAGSGAGA DRPNQPVTAA HQDHRTADGR GRLDGLQPPL HPLEGRGRGQ RQDVAAVRNP R*CDQPRADQ DGRVEPRPDL RQAVLAASLA HPRRNLFGGL GRAGQPPVSP RLCRPLGRRH DLILRWPALP RGWPGREHRA RQPEVR*RAG TAVLYPYLRP VRAVQHPRGE CRRPRFHLCA RRPAVPRVRP ADRGALHRHG RLHRSRLCPD APARLPLRAA HPRPRRNQAV RAAGRASLPD VAPADRRHPE HQARACPLGR HPAPGQLDQA GHRHRLADAA QVRQLPAPER TGRGPARAGP DRAHAVHPGL AAKC*TAPPR ACRPEQR*GA QLAGQGGVLQ PPWGNQGSEL RAAALPGQRP QPGDGGYRAV EHGVPGTRHP GVGRGRQAGG RRAAAIPVAA GLGAHQPNRR LRLAAEPQTG RREVSALTDA RKTL |
1. Schmitt R, Bernhard E, Mattes R.
Characterisation of Tn1721, a new transposon containing tetracycline resistance genes capable of amplification.. Mol Gen Genet. 1979 Apr 17;172(1):53-65. doi: 10.1007/BF00276215. PubMed ID:
377024
.
2. Allmeier H, Cresnar B, Greck M, Schmitt R. Complete nucleotide sequence of Tn1721: gene organization and a novel gene product with features of a chemotaxis protein.. Gene. 1992 Feb 1;111(1):11-20. doi: 10.1016/0378-1119(92)90597-i. PubMed ID: 1312499 .
3. Diver WP, Grinsted J, Fritzinger DC, Brown NL, Altenbuchner J, Rogowsky P, Schmitt R. DNA sequences of and complementation by the tnpR genes of Tn21, Tn501 and Tn1721.. Mol Gen Genet. 1983;191(2):189-93. doi: 10.1007/BF00334812. PubMed ID: 6312271 .
4. Zgur-Bertok D, Ambrozic J, Grabnar M. Tn5431 arose by transposition of Tn3 into Tn1721.. Can J Microbiol. 1996 Dec;42(12):1274-6. doi: 10.1139/m96-166. PubMed ID: 8989866 .
5. Rogowsky P, Schmitt R. Resolution of a hybrid cointegrate between transposons Tn501 and Tn1721 defines the recombination site.. Mol Gen Genet. 1984;193(1):162-6. doi: 10.1007/BF00327431. PubMed ID: 6318048 .
6. Grinsted J, de la Cruz F, Altenbuchner J, Schmitt R. Complementation of transposition of tnpA mutants of Tn3, Tn21, Tn501, and Tn1721.. Plasmid. 1982 Nov;8(3):276-86. doi: 10.1016/0147-619x(82)90065-8. PubMed ID: 6294711 .
7. Rogowsky P, Halford SE, Schmitt R. Definition of three resolvase binding sites at the res loci of Tn21 and Tn1721.. EMBO J. 1985 Aug;4(8):2135-41. doi: 10.1002/j.1460-2075.1985.tb03904.x. PubMed ID: 2998784 .
8. Pasquali F, Kehrenberg C, Manfreda G, Schwarz S. Physical linkage of Tn3 and part of Tn1721 in a tetracycline and ampicillin resistance plasmid from Salmonella Typhimurium.. J Antimicrob Chemother. 2005 Apr;55(4):562-5. doi: 10.1093/jac/dkh553. Epub 2005 Feb 24. PubMed ID: 15731203 .
9. Frech G, Schwarz S. Plasmid-encoded tetracycline resistance in Salmonella enterica subsp. enterica serovars choleraesuis and typhimurium: identification of complete and truncated Tn1721 elements.. FEMS Microbiol Lett. 1999 Jul 1;176(1):97-103. doi: 10.1111/j.1574-6968.1999.tb13648.x. PubMed ID: 10418136 .
10. Rogowsky P, Schmitt R. Tn1721-encoded resolvase: structure of the tnpR gene and its in vitro functions.. Mol Gen Genet. 1985;200(1):176-81. doi: 10.1007/BF00383332. PubMed ID: 2993811 .
11. Schmitt R, Motsch S, Rogowsky P, de la Cruz F, Grinsted J. On the transposition and evolution of Tn1721 and its relatives.. Basic Life Sci. 1985;30:79-91. doi: 10.1007/978-1-4613-2447-8_8. PubMed ID: 2990439 .
2. Allmeier H, Cresnar B, Greck M, Schmitt R. Complete nucleotide sequence of Tn1721: gene organization and a novel gene product with features of a chemotaxis protein.. Gene. 1992 Feb 1;111(1):11-20. doi: 10.1016/0378-1119(92)90597-i. PubMed ID: 1312499 .
3. Diver WP, Grinsted J, Fritzinger DC, Brown NL, Altenbuchner J, Rogowsky P, Schmitt R. DNA sequences of and complementation by the tnpR genes of Tn21, Tn501 and Tn1721.. Mol Gen Genet. 1983;191(2):189-93. doi: 10.1007/BF00334812. PubMed ID: 6312271 .
4. Zgur-Bertok D, Ambrozic J, Grabnar M. Tn5431 arose by transposition of Tn3 into Tn1721.. Can J Microbiol. 1996 Dec;42(12):1274-6. doi: 10.1139/m96-166. PubMed ID: 8989866 .
5. Rogowsky P, Schmitt R. Resolution of a hybrid cointegrate between transposons Tn501 and Tn1721 defines the recombination site.. Mol Gen Genet. 1984;193(1):162-6. doi: 10.1007/BF00327431. PubMed ID: 6318048 .
6. Grinsted J, de la Cruz F, Altenbuchner J, Schmitt R. Complementation of transposition of tnpA mutants of Tn3, Tn21, Tn501, and Tn1721.. Plasmid. 1982 Nov;8(3):276-86. doi: 10.1016/0147-619x(82)90065-8. PubMed ID: 6294711 .
7. Rogowsky P, Halford SE, Schmitt R. Definition of three resolvase binding sites at the res loci of Tn21 and Tn1721.. EMBO J. 1985 Aug;4(8):2135-41. doi: 10.1002/j.1460-2075.1985.tb03904.x. PubMed ID: 2998784 .
8. Pasquali F, Kehrenberg C, Manfreda G, Schwarz S. Physical linkage of Tn3 and part of Tn1721 in a tetracycline and ampicillin resistance plasmid from Salmonella Typhimurium.. J Antimicrob Chemother. 2005 Apr;55(4):562-5. doi: 10.1093/jac/dkh553. Epub 2005 Feb 24. PubMed ID: 15731203 .
9. Frech G, Schwarz S. Plasmid-encoded tetracycline resistance in Salmonella enterica subsp. enterica serovars choleraesuis and typhimurium: identification of complete and truncated Tn1721 elements.. FEMS Microbiol Lett. 1999 Jul 1;176(1):97-103. doi: 10.1111/j.1574-6968.1999.tb13648.x. PubMed ID: 10418136 .
10. Rogowsky P, Schmitt R. Tn1721-encoded resolvase: structure of the tnpR gene and its in vitro functions.. Mol Gen Genet. 1985;200(1):176-81. doi: 10.1007/BF00383332. PubMed ID: 2993811 .
11. Schmitt R, Motsch S, Rogowsky P, de la Cruz F, Grinsted J. On the transposition and evolution of Tn1721 and its relatives.. Basic Life Sci. 1985;30:79-91. doi: 10.1007/978-1-4613-2447-8_8. PubMed ID: 2990439 .