Mobile element type:
Transposon
Name:
Tn1331
Synonyms:
Accession:
Tn1331-KC354802.1
Family:
Tn3
Group:
Tn3
First isolate:
Yes
Partial:
ND
Evidence of transposition:
Yes
Host Organism:
Klebsiella pneumoniae strain Kp002
Date of Isolation:
2012
Country:
Australia
Molecular Source:
plasmid pJEG012
Name | Coordinates | Direction | Length | Sequence |
---|---|---|---|---|
IRL | 1-38 | + | 38 | GGGGTCTGAC GCTCAGTGGA ACGAAAACTC ACGTTAAG |
IRR | 7959-7996 | - | 38 | GGGGTCTGAC GCTCAGTGGA ACGAAAACTC ACGTTAAG |
Name | Associated TE | Coordinates | Orientation | Length | Sequence |
---|---|---|---|---|---|
attC bla OXA-9 core | Tn1331 | 1621-1689 | + | 69 | CGTTCAAGGT GAGCGGACTC GCGCGGCTTT ATGCGCGAGG TCCGCTCGAG CGCAGGGTTA TGCATCTGC |
attC aadA core | Tn1331 | 2536-2590 | + | 55 | GGTATCCTTC ATTGCTCCGC TGTGCGCTTA ATAGGTGCAT AACTTTGTTT TAGAC |
attC AAC(6')-Ib4 | Tn1331 | 3390-3444 , 4067-4071 | + | 60 | CGTTTGACAT GAGGGGCGGC CAAGGGCGCC AGCCCTTGGA CGTCCCCCTC GATGGTTCAA |
attC AAC(6')-Ib core | Tn1331 | 3390-3455 | + | 66 | CGTTTGACAT GAGGGGCGGC CAAGGGCGCC AGCCCTTGGA CGTCCCCCTC GATGGAAGGG TTAGGC |
res | Tn1331 | 4797-4917 | + | 121 | AAATGTACCT TAAATCGAAT ATCAGACACG ATGTGTCTAT TATGCCAAAA TGACGATTTA ATGGACACTC AAACGAAGCC GTTTTACTAT GTCTGATAAT TTATAACATT TCGGACGGTT G |
res_site_III_a | Tn1331 | 4800-4822 | + | 23 | TGTACCTTAA ATCGAATATC AGA |
res_site_II_a | Tn1331 | 4828-4863 | + | 36 | TGTGTCTATT ATGCCAAAAT GACGATTTAA TGGACA |
res_site_I | Tn1331 | 4886-4914 | + | 29 | TGTCTGATAA TTTATAACAT TTCGGACGG |
ORF Summary
Name | Associated TE | Coordinates | Orientation | Class | Subclass |
---|---|---|---|---|---|
bla TEM-1 (ARO:3000873) | Tn1331 | 148-1008 | - | Passenger Gene | Antibiotic Resistance |
tnpR_p | Tn1331 | 1191-1509 | - | Accessory Gene | Resolvase |
bla OXA-9 (ARO:3001404) | Tn1331 | 1708-2547 | - | Passenger Gene | Antibiotic Resistance |
aadA (ARO:3002601) | Tn1331 | 2592-3380 | - | Passenger Gene | Antibiotic Resistance |
AAC(6')-Ib4 (ARO:3002577) | Tn1331 | 3450-4004 | - | Passenger Gene | Antibiotic Resistance |
tnpR | Tn1331 | 4238-4795 | - | Accessory Gene | Resolvase |
tnpA | Tn1331 | 4958-7963 | + | Transposase |
ORF Details
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | bla TEM-1 (ARO:3000873) | Bla TEM-1 | Tn1331 | 286 | 148-1008 | - |
---|
Class: | Passenger Gene | ||||||||||
Subclass: | Antibiotic Resistance | ||||||||||
Function: | antibiotic inactivation (ARO:0001004) | ||||||||||
Sequence Family: | TEM beta-lactamase (ARO:3000014) | ||||||||||
Target: | penam (ARO:3000008)||monobactam (ARO:0000004)||cephalosporin (ARO:0000032)||penem (ARO:3003706) | ||||||||||
Comment: | strictmatch to reference sequence for ARO:3000873 (bitscore: 591) | ||||||||||
Protein Sequence: | MSIQHFRVAL IPFFAAFCLP VFAHPETLVK VKDAEDQLGA RVGYIELDLN SGKILESFRP EERFPMMSTF KVLLCGAVLS RVDAGQEQLG RRIHYSQNDL VEYSPVTEKH LTDGMTVREL CSAAITMSDN TAANLLLTTI GGPKELTAFL HNMGDHVTRL DRWEPELNEA IPNDERDTTM PAAMATTLRK LLTGELLTLA SRQQLIDWME ADKVAGPLLR SALPAGWFIA DKSGAGERGS RGIIAALGPD GKPSRIVVIY TTGSQATMDE RNRQIAEIGA SLIKHW |
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | tnpR_p | TnpR_p | Tn1331 | 106 | 1191-1509 | - |
---|
Class: | Accessory Gene | ||||||||||
Subclass: | Resolvase | ||||||||||
Sequence Family: | Serine Site-Specific Recombinase | ||||||||||
Transposase Chemistry: | Serine | ||||||||||
Comment: | C-terminal fragment | ||||||||||
Protein Sequence: | KRV*CSGCSG SVY*RRDQYR R*YGANGGHH PVGCGTG*TP EDPRAHE*GP TGSKAERNQI WPQAYRGQER RADASSEGHW CNGNCSSAQY CPLHGL*NS* RRKGLV |
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | bla OXA-9 (ARO:3001404) | Bla OXA-9 | Tn1331 | 279 | 1708-2547 | - |
---|
Class: | Passenger Gene | ||||||||||
Subclass: | Antibiotic Resistance | ||||||||||
Function: | antibiotic inactivation (ARO:0001004) | ||||||||||
Sequence Family: | OXA beta-lactamase (ARO:3000017) | ||||||||||
Target: | cephalosporin (ARO:0000032)||penam (ARO:3000008) | ||||||||||
Comment: | strictmatch to reference sequence for ARO:3001404 (bitscore: 569) | ||||||||||
Protein Sequence: | MKDTLMKKIL LLHMLVFVSA TLPISSVASD EVETLKCTII ADAITGNTLY ETGECARRVS PCSSFKLPLA IMGFDSGILQ SPKSPTWELK PEYNPSPRDR TYKQVYPALW QSDSVVWFSQ QLTSRLGVDR FTEYVKKFEY GNQDVSGDSG KHNGLTQSWL MSSLTISPKE QIQFLLRFVA HKLPVSEAAY DMAYATIPQY QAAEGWAVHG KSGSGWLRDN NGKINESRPQ GWFVGWAEKN GRQVVFARLE IGKEKSDIPG GSKAREDILV ELPVLMGNK |
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | aadA (ARO:3002601) | AadA | Tn1331 | 262 | 2592-3380 | - |
---|
Class: | Passenger Gene | ||||||||||
Subclass: | Antibiotic Resistance | ||||||||||
Function: | antibiotic inactivation (ARO:0001004) | ||||||||||
Sequence Family: | ANT(3'')(ARO:3004275) | ||||||||||
Target: | aminoglycoside antibiotic (ARO:0000016) | ||||||||||
Comment: | strict match to reference sequence for ARO:3002601 (bitscore: 520)||Synonym: ANT(9)(3'') | ||||||||||
Protein Sequence: | MREAVIAEVS TQLSEVVGVI ERHLEPTLLA VHLYGSAVDG GLKPHSDIDL LVTVTVRLDE TTRRALINDL LETSASPGES EILRAVEVTI VVHDDIIPWR YPAKRELQFG EWQRNDILAG IFEPATIDID LAILLTKARE HSVALVGPAA EELFDPVPEQ DLFEALNETL TLWNSPPDWA GDERNVVLTL SRIWYSAVTG KIAPKDVAAD WAMERLPAQY QPVILEARQA YLGQEDRLAS RADQLEEFVH YVKGEITKVV GK |
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | AAC(6')-Ib4 (ARO:3002577) | AAC(6')-Ib4 | Tn1331 | 184 | 3450-4004 | - |
---|
Class: | Passenger Gene | ||||||||||
Subclass: | Antibiotic Resistance | ||||||||||
Function: | antibiotic inactivation (ARO:0001004) | ||||||||||
Sequence Family: | AAC(6') (ARO:3000345) | ||||||||||
Target: | aminoglycoside antibiotic (ARO:0000016) | ||||||||||
Comment: | strict match to reference sequence for ARO:3002577 (bitscore: 380) | ||||||||||
Protein Sequence: | MTNSNDSVTL RLMTEHDLAM LYEWLNRSHI VEWWGGEEAR PTLADVQEQY LPSVLAQESV TPYIAMLNGE PIGYAQSYVA LGSGDGWWEE ETDPGVRGID LSLANASQLG KGLGTKLVRA LVELLFNDPE VTKIQTDPSP SNLRAIRCYE KAGFERQGTV TTPDGPAVYM VQTRQAFERT RSVA |
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | tnpR | TnpR | Tn1331 | 185 | 4238-4795 | - |
---|
Class: | Accessory Gene | ||||||||||
Subclass: | Resolvase | ||||||||||
Function: | resolvase||serine site-specific recombinase | ||||||||||
Sequence Family: | Serine Site-Specific Recombinase | ||||||||||
Transposase Chemistry: | Serine | ||||||||||
Comment: | first defined as a repressor | ||||||||||
Protein Sequence: | MRIFGYARVS TSQQSLDIQI RALKDAGVKA NRIFTDKASG SSTDREGLDL LRMKVEEGDV ILVKKLDRLG RDTADMIQLI KEFDAQGVAV RFIDDGISTD GDMGQMVVTI LSAVAQAERR RILERTNEGR QEAKLKGIKF GRRRTVDRNV VLTLHQKGTG ATEIAHQLSI ARSTVYKILE DERAS |
Gene Name | Protein Name | Associated TE | Gene Length | Coordinates | Strand | tnpA | TnpA | Tn1331 | 1001 | 4958-7963 | + |
---|
Class: | Transposase | ||||||||||
Function: | transposase | ||||||||||
Transposase Chemistry: | DDE | ||||||||||
Comment: | identical to tnpA (Tn1) | ||||||||||
Protein Sequence: | MPVDFLTTEQ TESYGRFTGE PDELQLARYF HLDEADKEFI GKSRGDHNRL GIALQIGCVR FLGTFLTDMN HIPSGVRHFT ARQLGIRDIT VLAEYGQREN TRREHAALIR QHYQYREFAW PWTFRLTRLL YTRSWISNER PGLLFDLATG WLMQHRIILP GATTLTRLIS EVREKATLRL WNKLALIPSA EQRSQLEMLL GPTDCSRLSL LESLKKGPVT ISGPAFNEAI ERWKTLNDFG LHADNLSTLP AVRLKNLARY AGMTSVFNIA RMSPQKRMAV LVAFVLAWET LALDDALDVL DAMLAVIIRD ARKIGQKKRL RSLKDLDKSA LALASACSYL LKEETPDESI RAEVFSYIPR QKLAEIITLV REIARPSDDN FHEEMVEQYG RVRRFLPHLL NTVKFSSAPA GVTTLNACDY LSREFSSRRQ FFDDAPTEII SRSWKRLVIN KEKHITRRGY TLCFLSKLQD SLRRRDVYVT GSNRWGDPRA RLLQGADWQA NRIKVYRSLG HPTDPQEAIK SLGHQLDSRY RQVAARLGEN EAVELDVSGP KPRLTISPLA SLDEPDSLKR LSKMISDLLP PVDLTELLLE INAHTGFADE FFHASEASAR VDDLPVSISA VLMAEACNIG LEPLIRSNVP ALTRHRLNWT KANYLRAETI TSANARLVDF QATLPLAQIW GGGEVASADG MRFVTPVRTI NAGPNRKYFG NNRGITWYNF VSDQYSGFHG IVIPGTLRDS IFVLEGLLEQ ETGLNPTEIM TDTAGASELV FGLFWLLGYQ FSPRLADAGA SVFWRMDHDA DYGVLNDIAR GQSDPRKIVL QWDEMIRTAG SLKLGKVQAS VLVRSLLKSE RPSGLTQAII EVGRINKTLY LLNYIDDEDY RRRILTQLNR GESRHAVARA ICHGQKGEIR KRYTDGQEDQ LGALGLVTNA VVLWNTIYMQ AALDHLRAQG ETLNDEDIAR LSPLCHGHIN MLGHYSFTLA ELVTKGHLRP LKEASEVENV A |
1. Espedido BA, Steen JA, Ziochos H, Grimmond SM, Cooper MA, Gosbell IB, van Hal SJ, Jensen SO.
Whole genome sequence analysis of the first Australian OXA-48-producing outbreak-associated Klebsiella pneumoniae isolates: the resistome and in vivo evolution.. PLoS One. 2013;8(3):e59920. doi: 10.1371/journal.pone.0059920. Epub 2013 Mar 29. PubMed ID:
23555831
.
2. Tolmasky ME, Crosa JH. Tn1331, a novel multiresistance transposon encoding resistance to amikacin and ampicillin in Klebsiella pneumoniae.. Antimicrob Agents Chemother. 1987 Dec;31(12):1955-60. doi: 10.1128/AAC.31.12.1955. PubMed ID: 2830842 .
3. Nobuta K, Tolmasky ME, Crosa LM, Crosa JH. Sequencing and expression of the 6'-N-acetyltransferase gene of transposon Tn1331 from Klebsiella pneumoniae.. J Bacteriol. 1988 Aug;170(8):3769-73. doi: 10.1128/jb.170.8.3769-3773.1988. PubMed ID: 2841303 .
4. Tolmasky ME, Colloms S, Blakely G, Sherratt DJ. Stability by multimer resolution of pJHCMW1 is due to the Tn1331 resolvase and not to the Escherichia coli Xer system.. Microbiology (Reading). 2000 Mar;146 ( Pt 3):581-589. doi: 10.1099/00221287-146-3-581. PubMed ID: 10746761 .
2. Tolmasky ME, Crosa JH. Tn1331, a novel multiresistance transposon encoding resistance to amikacin and ampicillin in Klebsiella pneumoniae.. Antimicrob Agents Chemother. 1987 Dec;31(12):1955-60. doi: 10.1128/AAC.31.12.1955. PubMed ID: 2830842 .
3. Nobuta K, Tolmasky ME, Crosa LM, Crosa JH. Sequencing and expression of the 6'-N-acetyltransferase gene of transposon Tn1331 from Klebsiella pneumoniae.. J Bacteriol. 1988 Aug;170(8):3769-73. doi: 10.1128/jb.170.8.3769-3773.1988. PubMed ID: 2841303 .
4. Tolmasky ME, Colloms S, Blakely G, Sherratt DJ. Stability by multimer resolution of pJHCMW1 is due to the Tn1331 resolvase and not to the Escherichia coli Xer system.. Microbiology (Reading). 2000 Mar;146 ( Pt 3):581-589. doi: 10.1099/00221287-146-3-581. PubMed ID: 10746761 .