IS Families

Fig.1.6.1. IS distribution in the prokaryotic world.

Prokaryotic Insertion Sequences (IS)

1. IS1 family 2. IS1595 family 3. IS3 family [updated on 04/10/22] 4. IS481 family 5. IS4 and related families 5a. IS701 family 5b. ISH3 family 5c. IS1634 family 6. IS5 and related IS1182 families 7. IS6 family [updated on 05/21/22] 8. IS21 family 9. IS30 family [updated on 05/21/22] 10. IS66 family 11. IS110 and IS1111 families 12. IS256 family 13. IS630 family 14. IS982 family 15. IS1202 family [New Family - under construction] 16. IS1380 family 17. ISAs1 family 18. ISL3 family 19. ISAzo13 family 20. IS607 family 21. IS91 and related ISCR families 22. IS200/IS605 family [updated on 02/21/22]

Quick Access Table: Main Characteristics and Summary of Each IS family and Sub-Groups

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Characteristics of insertion sequence families. Abbreviations: DR, duplication repeat; IS, insertion sequence; ORF, open reading frame.
Families	Sub-Groups	Typical size-range (bp)	DR (bp)	Ends	IRs	No ORFs	Frameshift	Catalytic residues	Mechanism
IS1	—	740–1180	8–9	GGnnnTG	Y	2	ORFAB	DDE	copy-and-paste and cointegrate
	single ORF	800–1200	0–9		N	1	—
	ISMhu11	900–4600	0–10		Y	2	ORFAB
IS1595	ISPna2	1000–1150	8	GGCnnTG	Y	1	—	DDNK	copy-and-paste (?)
	ISPna2+pass	1500–2600	8	—		1+pass		—
	ISH4	1000	8	CGCTCTT		1		DDNK
	IS1016	700–745	7–9	GGGgctg				DDEK
	IS1595	900–1100	8	CcTGATT				DDNK+ER4R7
	ISSod11	1000–1100	8	nnnGcnTATC				DDHK+ER4R7
	ISNwi1	1080–1200	8	ggnnatTAT				DDEK+ER4
	ISNwi1+pass	1750–4750	8	—		1+pass		—
	ISNha5	3450–7900	8	CGGnnTT		1		DDER/K
IS3	IS150	1200–1600	3–4	TG	Y	2	ORFAB	DDE	copy-and-paste
	IS407	1100–1400	4	TG
	IS51	1000–1400	3–4	TG
	IS3	1150–1750	3–4	TGa/g
	IS2	1300–1400	5	TG
IS481	—	950–1300	4–15	TGT	Y	1	—	DDE	copy-and-paste (?)
IS1202	—	1400–1700	5	TGT	Y	1	—	DDE	—
IS4	IS10	1200–1350	9	CT	Y	1	DDE	hairpin intermediate	cut-and-paste
	IS50	1350–1550	8–9	C				hairpin intermediate
	ISPepr1	1500–1600	7–8	-T-AA				?
	IS4	1400–1600	10–13	-AAT				?
	IS4Sa	1150–1750	8–10	CA				?
	ISH8	1400–1800	10	?
	IS231	1450–5400	10–12	CAT		1 or + *		*passenger genes
IS701	—	1400–1550	4	—	Y	1	—	DDE	—
	ISAba11	—	—
ISH3	—	1225–1500	4–5	C-GT	Y	1	—	DDE	—
IS1634	—	1500–2000	5–6	C	Y	1	—	DDE	—
IS5	IS903	950–1150	9	GG	Y	1	—	DDE	—
	ISL2	850–1200	2–3	—
	ISH1	900–1150	8	-GC
	IS5	1000–1500	4	Ga/g
	IS1031	850–1050	3	GAa/g
	IS427	800–1000	2–4	Ga/g		2	ORFAB
IS1182	—	1330–1950	0–60	—	Y	1	—	DDE	—
IS6	—	700–900	8	GG	Y	1	—	DDE	co-integrate
IS21	—	1750–2600	4–8	TG	Y	2 *	—	DDE	—
IS30	—	1000–1700	2–3	—	Y	1	—	DDE	copy-and-paste
IS66	—	2000–3000	8–9	GTAA	Y	3*	—	DDE*	—
	ISBst12	1350–1900				1		DDE
IS256	—	1200–1500	8–9	Ga/g	Y	1	—	DDE	copy-and-paste
	IS1249	1300	0–10	GG
	ISC1250	1250	0–9	GG
ISH6	—	1450	8	GGT	Y	1	—	DDE	—
ISLre2	—	1500–2000	9	—	Y	1	—	DDE	—
ISKra4	ISAzba1	1400–2900	0	—	Y	1 or + *	—	DDE	—
	ISMich2	1250–1400	8	GGG		1 or 2	ORFAB
	ISKra4	1400–3700	9	GGG		1 or + *	—
IS630	—	1000–1400	2*	—	Y	1 or 2	ORFAB	DDE	cut-and-paste
IS982	—	1000	3–9	AC	Y	1	—	DDE	—
IS1380	—	1550–2000	4–5	CC	Y	1	—	DDE	—
ISAs1	—	1200–1500	8–10	CAGGG	Y	1	—	—	—
ISL3	—	1300–2300	8	GG	Y	1	—	—	—
Tn3	—	>3000	0	GGGG	Y	>1	—	DDE	co-integrate
ISAzo13	—	1250–2200	0–4	Ga/g	Y	1	—	—	—
IS110	—	1200–1550	0	—	N	1	—	DEDD	—
	IS1111	—	—	—	Y*	—	—	—	—
IS91	—	1500–2000	0	—	N	1	—	HUH/Y2	rolling-circle
IS200/IS605	IS200	600–750	0	—	0	1*	—	HUH/Y1	peel-and-paste
	IS605	1300–2000	—	—	—	2*	—	HUH/Y1**
IS607	—	1700–2500	0	—	N	2*	—	Serine**	—
ISNCY *	IS892	1600	0–8	CTAG	Y	2	ORFAB	—	—
	ISLbi1	1400–1500	5	—	Y	1
	ISMae2	1400–2400	9	CAG	Y	1
	ISPlu15	800–1000	0	—	N	1
	ISA1214	1000–1200	8–12	—	Y	2
	ISC1217	1200	6–8	TAG	Y	1
	ISM1	1300–1600	8–9	—	Y	1
	ISDol1	1600–1900	6–7	—	Y	1	—	DDE	—

* ISNCY = Insertion Sequence Not Classified Yet

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