IS481
- Family IS481
- Group
Isoform Synonym(s)
Accession number | Transposition | Origin | Host |
---|---|---|---|
M22031 | ND | Bordetella pertussis | Bordetella holmesii Bordetella pertussis Tohama |
DNA section
IS Length : 1043 bp
Ends
IR Length : 22/23
IRL : TGTGAAGATTCAATAGGTTGTATGCATGGTTCATCCGAACCGGATTTGAG
IRR : TGTGAAGATTCAATAGGTTGTATTCGTCCAGGTTGAGTCTGGAGATGGGT
Insertion site
Left flank | Direct repeat | Right flank | DR Length |
---|---|---|---|
AAAGGGCGTCGGACG | GCTAGG | AGGGTTCAGGCGAAA | 6 |
DNA sequence
TGTGAAGATTCAATAGGTTGTATGCATGGTTCATCCGAACCGGATTTGAGAAACTGGAAATCGCCAACCCCCCAGTTCACTCAAGGAGCCCGGCCGGATG
AACACCCATAAGCATGCCCGATTGACCTTCCTACGTCGACTCGAAATGGTCCAGCAATTGATCGCCCATCAAGTTTGTGTGCCTGAAGCGGCCCGCGCCT
ATGGGGTCACCGCGCCGACTGTGCGCAAATGGCTGGGCCGCTTCCTGGCTCAGGGCCAGGCGGGCTTGGCCGATGCGTCCTCGCGCCCGACGGTCTCGCC
CCGAGCGATTGCGCCGGCCAAGGCGCTGGCTATCGTGGAGCTGCGCCGCAAGCGGCTGACCCAAGCGCGCATCGCCCAGGCGCTGGGCGTGTCAGCCAGC
ACCGTCAGCCGCGTCCTGGCCCGCGCCGGTCTGTCGCACCTGGCCGACCTGGAGCCGGCCGAGCCGGTGGTGCGCTACGAGCATCAGGCCCCCGGCGATC
TGCTGCACATCGACATCAAGAAGCTGGGACGTATCCAGCGCCCTGGCCACCGGGTCACGGGCAACCGACGCGATACCGTTGAGGGGGCCGGCTGGGACTT
CGTCTTCGTGGCCATCGATGACCACGCCCGCGTGGCCTTCACCGACATCCACCCCGACGAGCGCTTCCCCAGCGCCGTCCAGTTCCTCAAGGACGCAGTG
GCCTACTACCAGCGCCTGGGCGTGACCATCCAGCGCTTGCTCACCGACAATGGCTCGGCCTTTCGCAGCCGCGCCTTCGCCGCGCTGTGCCATGAGCTGG
GCATCAAGCACCGCTTTACCCGACCTTACCGCCCACAGACCAATGGCAAGGCCGAACGCTTCATCCAGTCGGCCTTGCGTGAGTGGGCTTACGCTCACAC
CTACCAGAACTCCCAACACCGAGCCGATGCCATGAAATCCTGGCTACACCACTACAACTGGCATCGACCCCACCAAGGCATCGGGCGCGCTGTACCCATC
TCCAGACTCAACCTGGACGAATACAACCTATTGAATCTTCACA
AACACCCATAAGCATGCCCGATTGACCTTCCTACGTCGACTCGAAATGGTCCAGCAATTGATCGCCCATCAAGTTTGTGTGCCTGAAGCGGCCCGCGCCT
ATGGGGTCACCGCGCCGACTGTGCGCAAATGGCTGGGCCGCTTCCTGGCTCAGGGCCAGGCGGGCTTGGCCGATGCGTCCTCGCGCCCGACGGTCTCGCC
CCGAGCGATTGCGCCGGCCAAGGCGCTGGCTATCGTGGAGCTGCGCCGCAAGCGGCTGACCCAAGCGCGCATCGCCCAGGCGCTGGGCGTGTCAGCCAGC
ACCGTCAGCCGCGTCCTGGCCCGCGCCGGTCTGTCGCACCTGGCCGACCTGGAGCCGGCCGAGCCGGTGGTGCGCTACGAGCATCAGGCCCCCGGCGATC
TGCTGCACATCGACATCAAGAAGCTGGGACGTATCCAGCGCCCTGGCCACCGGGTCACGGGCAACCGACGCGATACCGTTGAGGGGGCCGGCTGGGACTT
CGTCTTCGTGGCCATCGATGACCACGCCCGCGTGGCCTTCACCGACATCCACCCCGACGAGCGCTTCCCCAGCGCCGTCCAGTTCCTCAAGGACGCAGTG
GCCTACTACCAGCGCCTGGGCGTGACCATCCAGCGCTTGCTCACCGACAATGGCTCGGCCTTTCGCAGCCGCGCCTTCGCCGCGCTGTGCCATGAGCTGG
GCATCAAGCACCGCTTTACCCGACCTTACCGCCCACAGACCAATGGCAAGGCCGAACGCTTCATCCAGTCGGCCTTGCGTGAGTGGGCTTACGCTCACAC
CTACCAGAACTCCCAACACCGAGCCGATGCCATGAAATCCTGGCTACACCACTACAACTGGCATCGACCCCACCAAGGCATCGGGCGCGCTGTACCCATC
TCCAGACTCAACCTGGACGAATACAACCTATTGAATCTTCACA
Protein section
ORF number : 1
ORF 1
Length | Begin | End | Strand | Fusion ORF | |
---|---|---|---|---|---|
951 bp | 316 aa | 97 | 1047 | + | No |
Chemistry : DDE
ORF sequence :
MNTHKHARLTFLRRLEMVQQLIAHQVCVPEAARAYGVTAPTVRKWLGRFLAQGQAGLADASSRPTVSPRAIAPAKALAIVELRRKRLTQARIAQALGVSA
STVSRVLARAGLSHLADLEPAEPVVRYEHQAPGDLLHIDIKKLGRIQRPGHRVTGNRRDTVEGAGWDFVFVAIDDHARVAFTDIHPDERFPSAVQFLKDA
VAYYQRLGVTIQRLLTDNGSAFRSRAFAALCHELGIKHRFTRPYRPQTNGKAERFIQSALREWAYAHTYQNSQHRADAMKSWLHHYNWHRPHQGIGRAVP
ISRLNLDEYNLLNLHS
STVSRVLARAGLSHLADLEPAEPVVRYEHQAPGDLLHIDIKKLGRIQRPGHRVTGNRRDTVEGAGWDFVFVAIDDHARVAFTDIHPDERFPSAVQFLKDA
VAYYQRLGVTIQRLLTDNGSAFRSRAFAALCHELGIKHRFTRPYRPQTNGKAERFIQSALREWAYAHTYQNSQHRADAMKSWLHHYNWHRPHQGIGRAVP
ISRLNLDEYNLLNLHS
Blast result :
Comments
Bordetella pertussis is the aetiological agent of the human disease pertussis (whooping cough). IS481 differs from IS481v1 and IS481v2 at 8 and 5 positions, respectively. Proposal: DR = CTAG, rather than 0 (all the coordinates for all the iso-IS481 elements have been changed accordingly); although this assumption remains to be confirmed, the case of IS481v1 will perfectly fit with this proposal. IS481 is apparently absent from Bordetella parapertussis and Bordetella bronchiseptica (McLafferty et al., 1988). Note that IS481 harbors only one ORF. Moreover, no obvious translational frameshifting site can be seen. It has been shown that the promoter and transcritpion start site of the katA (catalase) gene was located inside the right IR of an IS481 element (DeShazer et al., 1984). A distantly-related 177-aa ORF (32 % identity from residues 160 to 290) has been found near the nod and nif genes of the Sym plasmid pRP2JI of Rhizobium leguminosarum biovar phaseoli (Yeoman et al., 1996, Accession Number X84099). It is most probably a vestigial element.
IS481 is also present in Bordetella holmesii (Accession number : AF349431), this sequence is shorter than those of database (1010 pb instead of 1045) and 99% DNA similar to tha database sequence.
IS481 is also present in Bordetella holmesii (Accession number : AF349431), this sequence is shorter than those of database (1010 pb instead of 1045) and 99% DNA similar to tha database sequence.
References
1] McPheat, W.L., and McNally, T. (1987) J. Gen. Microbiol. 133, 323-330.
2] McPheat, W.L., and McNally, T. (1987) FEMS Microbiol. Lett. 41, 357-360.
3] Park, I., Saurin, W., and Ullmann, A. (1988) FEMS Microbiol. Lett. 52, 19-24.
4] McLafferty, M.A., Harcus, D.R., and Hewlett, E.L. (1988) J. Gen. Microbiol. 134, 2297-2306.
5] McPheat, W.L., Hanson, J.H., Livey, I., and Robertson, J.S. (1989) J. Gen. Microbiol. 135, 1515-1520.
6] McPheat, W.L., Hanson, J.H., Livey, I., and Robertson, J.S. (1989) Mol. Microbiol. 3, 985-989.
7] Glare, E.M., Paton, J.C., Premier, R.R., Lawrence, A.J., and Nisbet, I.T. (1990) J. Clin. Microbiol. 28, 1982-1987.
8] DeShazer, D., Wood, G. E., and Friedman, R.L. (1994) Mol. Microbiol. 14, 123-130.
9] Yeoman, K.H., Hong, G.F., Mimmack, M.L., and Johnston, A.W.B. (1996) Plasmid 35, 121-130
2] McPheat, W.L., and McNally, T. (1987) FEMS Microbiol. Lett. 41, 357-360.
3] Park, I., Saurin, W., and Ullmann, A. (1988) FEMS Microbiol. Lett. 52, 19-24.
4] McLafferty, M.A., Harcus, D.R., and Hewlett, E.L. (1988) J. Gen. Microbiol. 134, 2297-2306.
5] McPheat, W.L., Hanson, J.H., Livey, I., and Robertson, J.S. (1989) J. Gen. Microbiol. 135, 1515-1520.
6] McPheat, W.L., Hanson, J.H., Livey, I., and Robertson, J.S. (1989) Mol. Microbiol. 3, 985-989.
7] Glare, E.M., Paton, J.C., Premier, R.R., Lawrence, A.J., and Nisbet, I.T. (1990) J. Clin. Microbiol. 28, 1982-1987.
8] DeShazer, D., Wood, G. E., and Friedman, R.L. (1994) Mol. Microbiol. 14, 123-130.
9] Yeoman, K.H., Hong, G.F., Mimmack, M.L., and Johnston, A.W.B. (1996) Plasmid 35, 121-130