IS1536
- Family IS607
- Group
Isoform Synonym(s)
Accession number | Transposition | Origin | Host |
---|---|---|---|
Z97182 | ND | Mycobacterium tuberculosis | Mycobacterium tuberculosis complex |
DNA section
IS Length : 1392 bp
Ends
IR Length :
IRL : GGGCTGCCAACTGTTGCGCGGTGAGTGGTCGGTAGTTGTCGGTGGCGTGC
IRR : GCCGTCTGGCACCAGGACCGGGCAGCATGCGCCGTCCGCGGTGGCGACCG
Insertion site
Left flank | Direct repeat | Right flank | DR Length |
---|
DNA sequence
GGGCTGCCAACTGTTGCGCGGTGAGTGGTCGGTAGTTGTCGGTGGCGTGCTGTAGGAACAGAGGTATGAATCTCGCGGCGTGGGCCGAGCGCAATGGCGT
CGCGCGGGTGACCGCGTATCGCTGGTTCCACGCTGGGCTCTTGCCGGTCCCGGCCCGGAAGGTTGGTCGACTCATTCTGGTCGACGAGCTGGCTAGCGAG
GCTGGCGCGCAGCCAAAGACTGCGGTGTACGCGCGGGTGTCGTCGGCTGATCAGAAGTCTGATTTGGATCGGCAGGTGGCGCGGGTGACTTCGTGGGCCA
CAGCCGAACAGATCCCGGTCGACAAGGTTGTCACCGAGGTCGGGTCGGTGCTCAACGGGCACCGACGTAAGTTCCCTGCGGTGCTGCGCGATCTGTCGGT
CACGCGGATTGTGGTTGAGCATCGGGATCGGTTCTGCCGGTTCGGTTCGGAGTATGTCCACGCTGCGCTGGCCGCTCAGGGTCGGGAGTTGGTCGTGGTG
GACTCGGCCGAGGTTGACGATGACCTGGTATGGGATATGACCGAGATTCTGACCTCGATGTGCGCAAGGTTGTATGGCAAACGTGCTGCTCAGAACCGGG
CCAAGCGGGCCGTCGCGGCTGCCGCTGTCGATGATCATGAGGCGGCCTGAGATGCCGCGTTTGGAGATCCCCAACGGCTGGTGTGTGCAAGCGTTCCGGT
TCACACTCGATCCGACCGCCGAGCAGGCACACGCGTTGGCGCGGCATTTCGGCGCCCGCCGCAAGGCCTACAACTGGACCGTCGCGCAGCTGAAAGCCGA
TATCCAAGCGTGGCGCGCGACCGGCGCCCAGACGGCGAAGCCGTCGCTTCGGGTACTGCGGAAACGCTGGAACACGGTGAAAGACGAGGTGTGTGTCAAC
GCCGAGACTGGCACCGTGTGGTGGCCGGAATGCTCGAAAGAGGCCTACGCCGACGGGATCGCGGGCGCGGTCGACGCGTACTGGAACTGGCAGCAGAGGC
GTGCTGGCAAGCGCGACGGCAAGAGAATGGGCTTCCCTCGATTCAAGAAGAAGGGCCGCGACGCCGATCGCGTGTCGTTCACCACGGGTGCGATGCGCGT
TGAGCCCGACCGTAGACACCTCACTTTGCCGGTGATCGGCTGCGTGCGTACGCATGAGAACACCCGCCGCATCGAGCGCCTCATCGCCAAAGACCGGGCG
CGGGTGCTGGCGATCACGGTGCGCCGCAACGGCACCCGGCTGGATGCGAGTGTGCGGGTACTGGTGCAGCGCCCCCAGCAACCCAACGTGGAACTGCCTG
AGTCGCGAATCGGTGTCGACGTGGGTGTTCGTCGTCTGGCCACGGTCGCCACCGCGGACGGCGCATGCTGCCCGGTCCTGGTGCCAGACGGC
CGCGCGGGTGACCGCGTATCGCTGGTTCCACGCTGGGCTCTTGCCGGTCCCGGCCCGGAAGGTTGGTCGACTCATTCTGGTCGACGAGCTGGCTAGCGAG
GCTGGCGCGCAGCCAAAGACTGCGGTGTACGCGCGGGTGTCGTCGGCTGATCAGAAGTCTGATTTGGATCGGCAGGTGGCGCGGGTGACTTCGTGGGCCA
CAGCCGAACAGATCCCGGTCGACAAGGTTGTCACCGAGGTCGGGTCGGTGCTCAACGGGCACCGACGTAAGTTCCCTGCGGTGCTGCGCGATCTGTCGGT
CACGCGGATTGTGGTTGAGCATCGGGATCGGTTCTGCCGGTTCGGTTCGGAGTATGTCCACGCTGCGCTGGCCGCTCAGGGTCGGGAGTTGGTCGTGGTG
GACTCGGCCGAGGTTGACGATGACCTGGTATGGGATATGACCGAGATTCTGACCTCGATGTGCGCAAGGTTGTATGGCAAACGTGCTGCTCAGAACCGGG
CCAAGCGGGCCGTCGCGGCTGCCGCTGTCGATGATCATGAGGCGGCCTGAGATGCCGCGTTTGGAGATCCCCAACGGCTGGTGTGTGCAAGCGTTCCGGT
TCACACTCGATCCGACCGCCGAGCAGGCACACGCGTTGGCGCGGCATTTCGGCGCCCGCCGCAAGGCCTACAACTGGACCGTCGCGCAGCTGAAAGCCGA
TATCCAAGCGTGGCGCGCGACCGGCGCCCAGACGGCGAAGCCGTCGCTTCGGGTACTGCGGAAACGCTGGAACACGGTGAAAGACGAGGTGTGTGTCAAC
GCCGAGACTGGCACCGTGTGGTGGCCGGAATGCTCGAAAGAGGCCTACGCCGACGGGATCGCGGGCGCGGTCGACGCGTACTGGAACTGGCAGCAGAGGC
GTGCTGGCAAGCGCGACGGCAAGAGAATGGGCTTCCCTCGATTCAAGAAGAAGGGCCGCGACGCCGATCGCGTGTCGTTCACCACGGGTGCGATGCGCGT
TGAGCCCGACCGTAGACACCTCACTTTGCCGGTGATCGGCTGCGTGCGTACGCATGAGAACACCCGCCGCATCGAGCGCCTCATCGCCAAAGACCGGGCG
CGGGTGCTGGCGATCACGGTGCGCCGCAACGGCACCCGGCTGGATGCGAGTGTGCGGGTACTGGTGCAGCGCCCCCAGCAACCCAACGTGGAACTGCCTG
AGTCGCGAATCGGTGTCGACGTGGGTGTTCGTCGTCTGGCCACGGTCGCCACCGCGGACGGCGCATGCTGCCCGGTCCTGGTGCCAGACGGC
Protein section
ORF number : 2
ORF 1
Length | Begin | End | Strand | Fusion ORF | |
---|---|---|---|---|---|
582 bp | 194 aa | 66 | 647 | + | No |
Chemistry : Serine
ORF sequence :
MNLAAWAERNGVARVTAYRWFHAGLLPVPARKVGRLILVDELASEAGAQPKTAVYARVSSADQKSDLDRQVARVTSWATAEQIPVDKVVTEVGSVLNGHR
RKFPAVLRDLSVTRIVVEHRDRFCRFGSEYVHAALAAQGRELVVVDSAEVDDDLVWDMTEILTSMCARLYGKRAAQNRAKRAVAAAAVDDHEAA
RKFPAVLRDLSVTRIVVEHRDRFCRFGSEYVHAALAAQGRELVVVDSAEVDDDLVWDMTEILTSMCARLYGKRAAQNRAKRAVAAAAVDDHEAA
Blast result :ORF 2
Length | Begin | End | Strand | Fusion ORF | |
---|---|---|---|---|---|
744 bp | 247 aa | 652 | 1395 | + | No |
AG : TnpB
ORF sequence :
MPRLEIPNGWCVQAFRFTLDPTAEQAHALARHFGARRKAYNWTVAQLKADIQAWRATGAQTAKPSLRVLRKRWNTVKDEVCVNAETGTVWWPECSKEAYA
DGIAGAVDAYWNWQQRRAGKRDGKRMGFPRFKKKGRDADRVSFTTGAMRVEPDRRHLTLPVIGCVRTHENTRRIERLIAKDRARVLAITVRRNGTRLDAS
VRVLVQRPQQPNVELPESRIGVDVGVRRLATVATADGACCPVLVPDG
DGIAGAVDAYWNWQQRRAGKRDGKRMGFPRFKKKGRDADRVSFTTGAMRVEPDRRHLTLPVIGCVRTHENTRRIERLIAKDRARVLAITVRRNGTRLDAS
VRVLVQRPQQPNVELPESRIGVDVGVRRLATVATADGACCPVLVPDG
Blast result :
Comments
IS1536 appears to be truncated at the right-hand end as it looses homology with other members of the IS1535 group. M. tuberculosis H37Rv genome position: 701363-702754. The IS1535 group includes IS1535, IS1536, IS1537, IS1538, IS1539 and IS1602. The putative Tpase show between 40,6 and 86,1 % identity, they contained two overlapping ORFs where the stop codon from upstream ORF overlapped the start codon of the downstream ORF (TGATG). ORF1 shows similarity to certain resolvase. ORF2 shows weak similarity with IS1136 of Saccharopolyspora erythrae and IS891 of Anabaena, members of the IS605 family.
References
1] Cole, S.T. et al., Nature 393, 537-544
2] Gordon, S.V. et al, Microbiology 145, 881-892
2] Gordon, S.V. et al, Microbiology 145, 881-892