ISRe46

  • Family IS481
  • Group
MGE type ISRelated element(s) :
Isoform Synonym(s) TnRErm46
Accession numberTranspositionOriginHost
KY494640 Y Rhodococcus equi
Rhodococcus equi
Rhodococcus hoagii
Rhodococcus hoagii PAM2350 plasmid pRErm46
DNA section
IS Length : 6907 bp

Ends


IR Length : 20/26

IRL : TGTTGCGGGTCATGACGTTGTTGACATCCGTTGCTCGGGACTGCCCCGCG
IRR : TGTATGAGGCCATGACGTTGGTGACACCGGCCTGAAGCTGGCTTGCAGGC

Insertion site


Left flankDirect repeatRight flankDR Length
CTCAATACTCCGGCCGCTAGAGGTAACTGTTGTTGCA6

DNA sequence

TGTTGCGGGTCATGACGTTGTTGACATCCGTTGCTCGGGACTGCCCCGCGCTCCTGATCGGTGCCCGTTCACTACAACTACGGTCGATTCGATACTGTCG
CCAGGAATCGACCTTCCGTGATCCAACTCTGCACCGACGTCACCCACGCGGTAGACCCGGCACCGTCTCAGCGTGTCTGACCGTCGGAGGAGGATCCGGC
TTTGGACGTGATCGACGGCCTGTAGCGCAGTGGGCTCGCGCGATTGGTGGTCCTCGACCAGTTCGGGCCTGTCGATTGCGAGAGCGAACTCCGCGTCCAC
CCGTCCCGGCCTCGGGTCGACCAGCACGAGGTTGCCCCCCGGCGTGCTTGCCGTCGTCGAATACCCCTTACCCATACTCCTAATCCCCTCCTTTGCATTT
AGCAATGTGAGCCTGAGCGGGAGTCAGTCGCCGGTACCGGCGTTCTTGATCCGGTGGAGTTCGTCGCGGACGATGTCGAGAGCCCAGCCGATGTCATCGC
CGGCGCTCTGGTGGAGCAGGTGTAATCCGAGTCCGTCGACGAGCGCAAGCAGACGCCGGCCGCCCGTGCTGCTTGCCGGGGACGGCGCCGCTGTTTCACC
GCGGAGCATCGCTGCGATGCGGGTGAACAGGTCGAGGAGCTGCCTGTGGGCGTGATCTCGGATCCGCGCAAGACCCGGGTGTGCGGGAGTCTCTGCAATC
AGGGCCACGTTGATCTCGAACTCGCGGCGCGTCTCCGGCGTCAAGGGCATGAGCTCACAGATCGCGGCCAGCGCATACGCGACCGCGTCGGCGCTCGGGG
TGATCGCGGTGACTCGCGCGGCAGCGCGCTCGACCATGAGCTCGGCGGAGAACTCCAGCAGCTCCGCCTGGGTCGAGAAGAGGTTGCGCAGCGATCCGAC
CGCCATCCCGGCCTCGGCGGCGACCGTCCGCACCGACACCGCGCTGATGCCGCGTTCTGCAATGATCCGCCAGACGGCCTCGGCCAGCCGGGCTTTGCGT
TCCTCGCGCGGGGCGACAGCCGTCACCATTCCTCCTAGTACGATCGTGCCAACTGCTGGTTGGTACGACTGTACTAAGGGGGCGTCATGCAGGACCACGA
CACGAGGGCGGACGGGGCGGCGCGGTGATCTCCGCCGAGGCAGCGGGCGCCCTTGCGGTGTTGGCGCTCACCGACTCGTTGAGTTTCGGCACGCTCCTGG
TGCCGGTCTGGCTGCTGATGACGCCGGGGCGGGTGCGGCCGCACCGCATCCTGCTCTACCTGGGCACCGTCGCGGCGGTCTACTACGGGATCGGGATCGC
GCTCATGGCCGGCGGCCGGTTCGTGATCGACAGCGCTGCGGGGTTGCTGGACACCACCGCCGCGACCGCCGCACGACTGGTCGTCGGCGCCGCGCTGTTG
GCGGCCAGCTTCGCCCTCGACACGAAAGCCGCTCGTGCTCGCGCCGCCGAGCGCGCGCAACAGTCAGGACGACTGAACCGCTGGCGCGAGCGCGCCATGA
GCGACAGTTCGACATCCACCCTGGTCGGGCTCGCGGTCGCCGCAGTGGCCCTCGAGGTTGCGTCGATGCTGCCGTACCTCGTCGCGACCGGGACCATCGC
CGACCAGACTCCCGGCTGGTCCACAGCCTTGCTGGTGTTGGCGGGGTACTGCCTGGTGATGGTCGCACCTGCGCTGGTGCTCACCGCTGGACGGCTCGTG
GCCCGCTCCGCCGTCGAGGTACCACTGAAACGACTCGACACGTGGCTGACACGCAACGCTCGGACCACGACGCTGTGGATCATCGGTATCGCCGGATTCT
TCCTCGCCGCCACCGCGCTTCAAGACCTCGGCTGGGTACCGCGCTGACTCACAACGGCCGGTCCGACAACCACGTTGATGAAACCGCTGGCTATTCCCTA
TGCCGTGGTCATACCTCGATCTGTTCACCGTGGGCCTGTGAACGCGGCGACTCCCTCGCCGGTTCACCGCAAAGTCAATCGGACTCGGGCAGTCCCTCCG
CCAAATTCGATAGCGGTTCTGTGGTGCTTCCTCTACGGTTCCGTTTCATGTATGCAAGCACTGGATTCATGAAGCCGTGGTCGCTCCGCTGACGGCGGCG
ACTCGTATCTCATCGATCTCCTGAGGCCGCCGTCCGGGTAGTTAGGCCGGGCGGTACTTCGTGCTGTCCCGGCTCCATCCTCGAGCTGCGGAGAATCAGT
GTCTACACCCCACACGGGCCGAAGTGGCCTGCCCAACACACCTAGCCCTTCGAGCGAAAGCTCCTCTTCCACCGACCGATTGCCTGCTGGTGCACACGCG
CATATCCGGGCAACCTCGGTTCATGTCATTCTCGGGTCGCGGCCGATCCTGACGGACGTCTCCGTCACACTGTCAGCCCGCTCGCGGCTTGCGATCGTCG
GAGAGAACGGGCGCGGCAAGACCACACTGCTCCACGTTCTCGCGGGGCTGCTGCAGCCCGACAGCGGGACGGTCAGCCGCGTCGGCGCTGTCGGTGTGGC
GCAGCAGGCCATACCTTTTCGAAAAGGTGAGACCATCGGCACACTGGTCGCGGACACCGTCGAGCCTGCCCTGCAGGCATTGCGGGAACTCGACGCTGCG
ACGCTCTTGATCGCGGACGGAGCGCCGGGCGGCGACGACGCCTACGCGGCGGCGTTGGAATCAGCAACCAGACTCGAGGCCTGGGATACCGAACGCCGAG
TCGACGTCGCCCTCGAAGCGCTGCATGCGTGCACGGACCGGGAGCGACCACTTCACACGCTGTCCGTCGGACAACGCTATCGAGTCCGGCTGGCCTGCCT
GCTGGGCGCCACACACGACATCCTGCTGTTGGACGAGCCGACGAATCACCTCGACAGCGACGGACTGGACTTCCTCACCGATCGGCTGCGCACCCACTCC
GGCGGACTGGCCATCGTCAGTCACGACCGCGCGCTCCTGCATGATGTCGCCGACGAGTTCCTTGACCTGGACCCGAGCCAGAACGATCGGCCGCAACTCT
TCGCCGGAGGTTACGAGGGGTGGCAGGAGGGCCGTCGTCGGGCCCGCGACCGGTGGGAACACGAATACCAGGACCAACTCGCCGAACGAGCACGCCTTCA
AGAAGCTGTCGCCGGCGCGCGCGACCGACTCAGCACCGGTTGGAGACCCGAGAAGGGCCACGGCAAGCACCAGCGCCAATCCCGCGCACCAGGTCTGGTG
CAGGCTCTCAAGCGACGCCAATCAGACCTCGAAGCCCACACGATCACCGTGCCGGAACCGCCACTGCGACTGAGGTTCCCGGCTCTCACCGTCCGTTCCA
GCACGCCGCTACTCCGCTGCGACGGCATCACCGTGTCAGAGCGACTGAATACCCCCATCTCGTTCTCACTCGACGCAGGGGAACGTCTCCTGGTGACCGG
CCACAACGGCGCAGGCAAATCCACCCTGCTCGCCGTGCTGGCCGGCGACCTGGAACCGTCCACTGGCGGAATCCGCCACCATACGGCTGCCCGTGTCGCC
CTCGTCGGCCAGGAAGTGCCGGCATGGGAGGCCGAACTGACCGCGCAGGAACTCTACGACCGCCACATCCGGAGTCTCGATCTACACCACAGAATCGAAC
CGCTACCGCTGACATCGACCGGGCTGCTGGAGAAGCAATCTCAACGCACACCCATCGGGCGACTGTCGCAGGGGCAGCAGCGCAGACTTCATCTCGCGAT
GCAGCTCGCTTCCCGCCCCACAGTCCTCATCTGCGACGAACCCACCAACCACCTATCGGTATCCCTGGTCGATGAGCTCACCGCCGCACTGTCAAACACT
CCAGCGGCCGTAGTGGTAGCCACACACGACCGCCAGATGCTCACCGACCTCGCTGGCTGGCCCCGCCTGCACCTGATGGGAGATCGTCCATGACGCGGTA
GCACCCCCACTGGAGCGGGGCATAGGACCCGCACTCCGCCCTCGCCGGCAGGTGCGGGTTCTCCTGTTCTCACCCAGCTCATCGGCGTCGCCGGATTCTT
CCTCACTGCCACTGCCACTGCCACTGCCACTGCACTCCAAGACCTCGGCTGGGCCGCGCGGGAGTGTCAGATTTCCGGTGGATCCGGTTCTGGCGCATCG
GTTTAGTTCTCACTCGGGGTGATCCGGCCCTCGAACGTGATCGCGAACGCGTTCAGTGCCGGCTTCCACCTCATCGCTACGGTCGATTCGACATCGTCGC
CAGGAACCAGCCTTCCGTGATCCAACTCCGCACCGACGTCACCAACGCGGTGGGCTCACGGCGCAGCAAACAGCCGGAAACGGCGGCCACTGATGGCTTC
TGCCACCCGTTGGGCGCTGCGCTCTTCCGGTTCGTCCGACGTGTCGAGTGCATGGCTTTCGAGCTCGGCGAGGTCGGAGAACTGATCCCACATGGAGAGG
ATCGGCCCCTCGTCGATCAAAGCGTTCGGCGCGGTTCGGGCTTGGGCTCGCTGCAGCGTGATATCGCGCTGTGGCCGGAGCACAATGTAGTGGACCGCCA
GCTCCGGGTGCTGTGCTGCTCGGGTTCGGAAGTGGTCGAGCATCCACGGCCCCACGATTCCGTCGATCACCGTGGTGAAGCCGCCGAGCGCATAGGTATA
GGCGGCGCCAGCGATCACATCCATGACGGTCTGGTTCTGCGCATCGGACGCGGGTTCGTACGGGGGTATCGCACCCGAGACGATGAAGTGCCAGAAGTCG
TCCGTGTGCAGATGAACGCCCTTGCTGGAACAGCGGGCGAGCTTCGCGGCGAGGGTGGACTTGCCGGCCCCGGGTGGGCCGGTCAGGATGATCACGTGTC
CGGTCACGGACGACAAGCTACCTCCTATCCTCGTGCCTGAAGTACCCAATTTCTGCCGGCCGGGGGCCGCTGCCGCGGAGCCAAGTCCTATGGAGTCGAT
CTGCAACGAGTGATCCCGACTCGCATCCATGTTGTAGGGTGCGGCCGTGGGAAATACGAACATCGCAGTGACCGAGTTCCGCCGCTTCTAGCGGCGGAGA
GCGAACTTTCAAACACGCTCCGCCGCTTTCAGCACGTCAGTTGCTGGGCGGCGTCTTTGTGCTGCCCGGGCCACCCCACTATTGCCCGGAGTTCATACCC
CATGCCTACCTACCGTTCCGGCCGTCACGAGCTCGGCCAGAACTTCCTCACGGACCGCAAAGCAGTCGATACGATCGTCGACCTCGTTTCTCGAACAGAC
GGCCCGATCATCGAAATCGGCTCCGGCGGTGGGGCGTTGACATTGCCCCTGCAGGCGCTGCGTCGACCGATCACAGCTATCGAGATCGATCCGCGACATG
TGCAAAAGCTCCAACATCGCGTCGATCCGAGTACGACGGTCGTGCACGGCGACTTCCTGCGCTACCGACTGCCCCGAACACCGCACACCATCGTGGGGAA
CTTGCCGTTCCACCACACCACGGCGATGTTGCGGCGAATCCTCCACGCCGAACACTGGACAGCGTCGGTCCTGCTCGTGCAGTGGGAGGTTGCACGTCGT
CGTGCGGCGGTCGGTGGCGCAACGATGATGACTGCGCAATGGTGGCCGTGGTACGACTTCGGCCTGGCCGGCCGTGTTTCCGCATCGGCGTTCACACCAC
GGCCGGGAGTCGATGCAGGGCTGATGACCATCGCTCGGCGGACCGTTCCACTCGTCGACCCCGCGCTACGTCCCCGATACAGCACCTTCGTCCACACCGT
CTTCACCAGCAAGGGCCACGGCCTGCATCAGATCTTGCCGCGGGTGGCTGGCGATCCTGAGAAGGCCGCGGTTAAGAAGTGGCTCGCTGGCCAGCGATTT
CGAGGCACACCGCTGCCGCGCGACCTCTCACCCGGACAATGGTCCGAGCTCTTCGCGATCATCGATCGACGCTCTCCGGCTACCGATCGGAAGCGGGCTG
AGTACCGGCGATGACGCACCCCAACGCCCCGTTGTCTGTGGAAGGCCGTCGACGGCTCGTCGAGCGATGTCAGACTCGTCCGATCTCCCACGTCGCTGCC
GAGATGGGCATCTCCCGCGCCTGTGCCAGCAAATGGGTGCACCGCTACCGCGAGTTCGGTGAGAGCGGTCTGCTGGACCGCCCTAGCATCCCGCACCGCC
AGCCCACTGCCACCGCAGCGGAGGTCGTCACCCGGATCGAGCGCCTGCGCCGAGAGAAGAAATGGTCGGCCCGGCGCATCGCCCTCGAACTCGCCAATGA
CGGCGTCGTCATCTCGGTGCGGACCGTCAGCAGGCACCTGGCCCACCTCGGGTTGAACCGGCGCAGGTTCCTCGACCCGTCCGGTGAGAGCAACCGCGCA
CCACGACGGATCGTCGCCCGCTGGCCCGGCCACATGGTCCACGTCGACGTCAAGAAGGTCGGCCGCATCCCCGACGGCGGCGGTTGGCGTGCCCACGGCC
GCGGCAGCGACCACGCCAAGGCGGTCGACCGAGCAAAGACCGCCGGCGCCCGCGCCGGATACATCTACCTGCACTCGGCGATCGACGGGTTCTCCCGCCT
CGCCTACACCGAAGCTCTCACTGACGAGAGAGCTTCCACTGCAATCGCGTTCATGCACCGTGCCCGAGCGTTCTTCGCCGCCCACGGCATCGAACACATT
CACCGCATCGTCACCGACAACGGCGCCTGCTACCGCGCGAAAGACTTCGTCAAGGTGCTGCACGGAGCGAGGCATCAGCGGATCACCCCGTACACCCCGC
GCCACAACGGCAAAGTCGAGCGCTACAACAGGATCCTCGCCGAGGAGTTCCTCTACGCGCGCACCTGGACCAGCGAAACCCAACGCTCCGAGGCTCTGCA
GGTATGGAATATCCACTACAACTACCACCGGCCCCACACCTCACTCAGCGACCGGCCGCCTGCAAGCCAGCTTCAGGCCGGTGTCACCAACGTCATGGCC
TCATACA
Protein section
ORF number : 7

 

ORF 2
LengthBeginEndStrandFusion ORF
603 bp200 aa1026424-No
ORF function : Passenger Gene
Annotation : TetR Tetracycline repressor protein class ADescription : Antibiotic resistance

ORF sequence :

MTAVAPREERKARLAEAVWRIIAERGISAVSVRTVAAEAGMAVGSLRNLFSTQAELLEFSAELMVERAAARVTAITPSADAVAYALAAICELMPLTPETR
REFEINVALIAETPAHPGLARIRDHAHRQLLDLFTRIAAMLRGETAAPSPASSTGGRRLLALVDGLGLHLLHQSAGDDIGWALDIVRDELHRIKNAGTGD

 

Blast result :
ORF 6
LengthBeginEndStrandFusion ORF
813 bp270 aa51025914-No
ORF function : Passenger Gene
Annotation : Erm(46)rRNA methyltransferaseDescription : Antibiotic resistance

ORF sequence :

MPTYRSGRHELGQNFLTDRKAVDTIVDLVSRTDGPIIEIGSGGGALTLPLQALRRPITAIEIDPRHVQKLQHRVDPSTTVVHGDFLRYRLPRTPHTIVGN
LPFHHTTAMLRRILHAEHWTASVLLVQWEVARRRAAVGGATMMTAQWWPWYDFGLAGRVSASAFTPRPGVDAGLMTIARRTVPLVDPALRPRYSTFVHTV
FTSKGHGLHQILPRVAGDPEKAAVKKWLAGQRFRGTPLPRDLSPGQWSELFAIIDRRSPATDRKRAEYRR

 

Blast result :
ORF 1
LengthBeginEndStrandFusion ORF
366 bp121 aa37510-No
ORF function : Passenger Gene
Annotation : Hypothetical proteinDescription :

ORF sequence :

MGKGYSTTASTPGGNLVLVDPRPGRVDAEFALAIDRPELVEDHQSREPTALQAVDHVQSRILLRRSDTLRRCRVYRVGDVGAELDHGRSIPGDSIESTVV
VVNGHRSGARGSPEQRMSTTS

 

Blast result :
ORF 3
LengthBeginEndStrandFusion ORF
723 bp240 aa11251847+No
ORF function : Passenger Gene
Annotation : Putative membrane proteinDescription :

ORF sequence :

MISAEAAGALAVLALTDSLSFGTLLVPVWLLMTPGRVRPHRILLYLGTVAAVYYGIGIALMAGGRFVIDSAAGLLDTTAATAARLVVGAALLAASFALDT
KAARARAAERAQQSGRLNRWRERAMSDSSTSTLVGLAVAAVALEVASMLPYLVATGTIADQTPGWSTALLVLAGYCLVMVAPALVLTAGRLVARSAVEVP
LKRLDTWLTRNARTTTLWIIGIAGFFLAATALQDLGWVPR

 

Blast result :
ORF 4
LengthBeginEndStrandFusion ORF
1695 bp564 aa21993893+No
ORF function : Passenger Gene
Annotation : Putative ABC transporter ATP-binding proteinDescription :

ORF sequence :

MSTPHTGRSGLPNTPSPSSESSSSTDRLPAGAHAHIRATSVHVILGSRPILTDVSVTLSARSRLAIVGENGRGKTTLLHVLAGLLQPDSGTVSRVGAVGV
AQQAIPFRKGETIGTLVADTVEPALQALRELDAATLLIADGAPGGDDAYAAALESATRLEAWDTERRVDVALEALHACTDRERPLHTLSVGQRYRVRLAC
LLGATHDILLLDEPTNHLDSDGLDFLTDRLRTHSGGLAIVSHDRALLHDVADEFLDLDPSQNDRPQLFAGGYEGWQEGRRRARDRWEHEYQDQLAERARL
QEAVAGARDRLSTGWRPEKGHGKHQRQSRAPGLVQALKRRQSDLEAHTITVPEPPLRLRFPALTVRSSTPLLRCDGITVSERLNTPISFSLDAGERLLVT
GHNGAGKSTLLAVLAGDLEPSTGGIRHHTAARVALVGQEVPAWEAELTAQELYDRHIRSLDLHHRIEPLPLTSTGLLEKQSQRTPIGRLSQGQQRRLHLA
MQLASRPTVLICDEPTNHLSVSLVDELTAALSNTPAAVVVATHDRQMLTDLAGWPRLHLMGDRP

 

Blast result :
ORF 5
LengthBeginEndStrandFusion ORF
561 bp186 aa48164256-No
ORF function : Passenger Gene
Annotation : ATPaseDescription :

ORF sequence :

MSSVTGHVIILTGPPGAGKSTLAAKLARCSSKGVHLHTDDFWHFIVSGAIPPYEPASDAQNQTVMDVIAGAAYTYALGGFTTVIDGIVGPWMLDHFRTRA
AQHPELAVHYIVLRPQRDITLQRAQARTAPNALIDEGPILSMWDQFSDLAELESHALDTSDEPEERSAQRVAEAISGRRFRLFAAP

 

Blast result :
ORF 7
LengthBeginEndStrandFusion ORF
1002 bp333 aa59116912+No
ORF function : Transposase
Chemistry : DDE

ORF sequence :

MTHPNAPLSVEGRRRLVERCQTRPISHVAAEMGISRACASKWVHRYREFGESGLLDRPSIPHRQPTATAAEVVTRIERLRREKKWSARRIALELANDGVV
ISVRTVSRHLAHLGLNRRRFLDPSGESNRAPRRIVARWPGHMVHVDVKKVGRIPDGGGWRAHGRGSDHAKAVDRAKTAGARAGYIYLHSAIDGFSRLAYT
EALTDERASTAIAFMHRARAFFAAHGIEHIHRIVTDNGACYRAKDFVKVLHGARHQRITPYTPRHNGKVERYNRILAEEFLYARTWTSETQRSEALQVWN
IHYNYHRPHTSLSDRPPASQLQAGVTNVMASYS

 

Blast result :
Comments
ISRe46 is 91% aa (transposase) similar to ISRae1.
In the publication, notice that only the transposase is named ISRe46, this is confusing. According to the nomenclature, the name is attributed to the insertion sequence, so we designated all the sequence as ISRe46 and add TnRErm46 as synonym.
References