ISPa1635
- Family IS4
- Group IS4
Isoform Synonym(s)
Accession number | Transposition | Origin | Host |
---|---|---|---|
AY539834 | ND | Pseudomonas aeruginosa | Pseudomonas aeruginosa isolate 290 |
DNA section
IS Length : 1635 bp
Ends
IR Length : 14/15
IRL : CAATGTCATCAACTTTGGAAATTATCCATAAATATCATATAATTAGCGCT
IRR : CAATGTCATCAACCTAAGCTGCAGCCCTGCCCAAGGCAAGCCCCCCGAAG
Insertion site
Left flank | Direct repeat | Right flank | DR Length |
---|---|---|---|
NNNNNNNNNN | GGCGGTCGGT | NNNNNNNNNN | 10 |
DNA sequence
CAATGTCATCAACTTTGGAAATTATCCATAAATATCATATAATTAGCGCTCAAATCAGTGCATGGGAGAAGCCCTTTTGACTACCTATACCGCATCGCTT
GACACCGCCAGCCAAACCCTGGCTTGAAAATTGTACAAAAAATAACCAGCCCGCTCGATTGTCCCGCCTTCATCGCCGCCCACCGCCAGAATCCTCAAGA
CTTTACCCGCCGACGCCAGCTCACCTTCAAGAACCTCGTCCTGTTCCTGCTCAATCAGCCGCGCACGGCCCTGCAAACCGAACTCGATCAGTTCTATCGC
GTACTCAATCAGGCGTCGACTGAGACGCAAATGGTCACTGCGCAGGCCTTCTGCAAAGCGCGCAAAAAGCTCAACCCCGAGGTATTTGAAAGTCTCAATC
GCCTCCTGCAGCAACAAATTGACTGCTTCGGGCTGCGTCAGAAGTGGCGTGGGCTGAGGGTGCTCGCGGTGGATGGCTCGACCGTGCATTTACCCCTGGA
GTCGACCATGGCGACCTTCTTTGGCAGTCACTCTGGCTTTCCCATGGCTCGCTTGTCCACACTCTACGAAGTCGCTGACGGTCAAACCTTGCATAGCCTG
ATCGTGCCCCTGACCGTCGGCGAGCGCGACTGTGCCCATCTGCACCTTGAGCACCTGCCGGCTGACAGCCTGACGCTGTTTGACCGTGGTTACCCTGGGC
ACTGGTTATTCGCGCTGTTCGCGCAGCAACAGCGGCACTTTCTGATGCGCCTGCCCTGTGGCTATAACGCCCAGGTCAAAGCGTTTCTACACTCTGGCCA
AGTTGAAGACACACAGCTTTTCGTGGCCAACCATCCTGAAGCACGTCTGTTCTGCTCCGAGGCTGGCGTTGATCCTGCCAGCCAGATCGAGCTGAGACTG
ATCCGGGTCGAGTTGGCCAACGGCGAAAGCGAAGTATTGCTGACCTCGCTGCTGGATCGAGAAGCCTTTCCCGCTGAGGTGTTTGCCGAGCTTTACCACC
GCCGCTGGGGCATCGAAACCGATTTCCGTCGCCTCAAACAAACCCTGACGCTGGACAACTTCAGCGGCCGCAGCGTGACCGCTGTAAAGCAGGACTTTCA
TGCCGCTCAACTGTTGAAGAACCTGGCGCTGTTGATGCAGCACCTGCTACAGCCGGTCATCGAACAGCGCCACAAAGGTCGCAAGCTGCGATGGAAAGTC
AACTTCACCCAAGGCGTGTCACGGCTCAAAAATACCCTGGTCGAGCTGCTGGTGCGGCACTGTGCTCAGGGGCTGAGCAATGTGCTGGCCTTGATGGCTA
AAAGCCTCAGTGCCGTACGCTCAGGCCGTAGCTTTGCGCGCCAACGCAAACGCGCAGCCAGCCGAGGTTGTGAGGGCTACAAACCGACGCGCTGAAGAAA
CACCACCGCCCAACCTCCGTGCAAAAAAGCTGGCCACAAGCGGTCGGCATAGGCTCGTCCGGAGGACGAGAAATCTCGCCTAGACAGCCGGAACAGACGA
TGATCACATCACCGCCAGCCCAGCTAGACCGCCTGATTGAGCGGCAGAGGCCTGGTCATCGCCCGACGGCCATGGCGGCTGGCTGCTTCGGGGGGCTTGC
CTTGGGCAGGGCTGCAGCTTAGGTTGATGACATTG
GACACCGCCAGCCAAACCCTGGCTTGAAAATTGTACAAAAAATAACCAGCCCGCTCGATTGTCCCGCCTTCATCGCCGCCCACCGCCAGAATCCTCAAGA
CTTTACCCGCCGACGCCAGCTCACCTTCAAGAACCTCGTCCTGTTCCTGCTCAATCAGCCGCGCACGGCCCTGCAAACCGAACTCGATCAGTTCTATCGC
GTACTCAATCAGGCGTCGACTGAGACGCAAATGGTCACTGCGCAGGCCTTCTGCAAAGCGCGCAAAAAGCTCAACCCCGAGGTATTTGAAAGTCTCAATC
GCCTCCTGCAGCAACAAATTGACTGCTTCGGGCTGCGTCAGAAGTGGCGTGGGCTGAGGGTGCTCGCGGTGGATGGCTCGACCGTGCATTTACCCCTGGA
GTCGACCATGGCGACCTTCTTTGGCAGTCACTCTGGCTTTCCCATGGCTCGCTTGTCCACACTCTACGAAGTCGCTGACGGTCAAACCTTGCATAGCCTG
ATCGTGCCCCTGACCGTCGGCGAGCGCGACTGTGCCCATCTGCACCTTGAGCACCTGCCGGCTGACAGCCTGACGCTGTTTGACCGTGGTTACCCTGGGC
ACTGGTTATTCGCGCTGTTCGCGCAGCAACAGCGGCACTTTCTGATGCGCCTGCCCTGTGGCTATAACGCCCAGGTCAAAGCGTTTCTACACTCTGGCCA
AGTTGAAGACACACAGCTTTTCGTGGCCAACCATCCTGAAGCACGTCTGTTCTGCTCCGAGGCTGGCGTTGATCCTGCCAGCCAGATCGAGCTGAGACTG
ATCCGGGTCGAGTTGGCCAACGGCGAAAGCGAAGTATTGCTGACCTCGCTGCTGGATCGAGAAGCCTTTCCCGCTGAGGTGTTTGCCGAGCTTTACCACC
GCCGCTGGGGCATCGAAACCGATTTCCGTCGCCTCAAACAAACCCTGACGCTGGACAACTTCAGCGGCCGCAGCGTGACCGCTGTAAAGCAGGACTTTCA
TGCCGCTCAACTGTTGAAGAACCTGGCGCTGTTGATGCAGCACCTGCTACAGCCGGTCATCGAACAGCGCCACAAAGGTCGCAAGCTGCGATGGAAAGTC
AACTTCACCCAAGGCGTGTCACGGCTCAAAAATACCCTGGTCGAGCTGCTGGTGCGGCACTGTGCTCAGGGGCTGAGCAATGTGCTGGCCTTGATGGCTA
AAAGCCTCAGTGCCGTACGCTCAGGCCGTAGCTTTGCGCGCCAACGCAAACGCGCAGCCAGCCGAGGTTGTGAGGGCTACAAACCGACGCGCTGAAGAAA
CACCACCGCCCAACCTCCGTGCAAAAAAGCTGGCCACAAGCGGTCGGCATAGGCTCGTCCGGAGGACGAGAAATCTCGCCTAGACAGCCGGAACAGACGA
TGATCACATCACCGCCAGCCCAGCTAGACCGCCTGATTGAGCGGCAGAGGCCTGGTCATCGCCCGACGGCCATGGCGGCTGGCTGCTTCGGGGGGCTTGC
CTTGGGCAGGGCTGCAGCTTAGGTTGATGACATTG
Protein section
ORF number : 1
ORF 1
Length | Begin | End | Strand | Fusion ORF | |
---|---|---|---|---|---|
1062 bp | 354 aa | 331 | 1392 | + | No |
Chemistry : DDE
ORF sequence :
MVTAQAFCKARKKLNPEVFESLNRLLQQQIDCFGLRQKWRGLRVLAVDGSTVHLPLESTMATFFGSHSGFPMARLSTLYEVADGQTLHSLIVPLTVGERD
CAHLHLEHLPADSLTLFDRGYPGHWLFALFAQQQRHFLMRLPCGYNAQVKAFLHSGQVEDTQLFVANHPEARLFCSEAGVDPASQIELRLIRVELANGES
EVLLTSLLDREAFPAEVFAELYHRRWGIETDFRRLKQTLTLDNFSGRSVTAVKQDFHAAQLLKNLALLMQHLLQPVIEQRHKGRKLRWKVNFTQGVSRLK
NTLVELLVRHCAQGLSNVLALMAKSLSAVRSGRSFARQRKRAASRGCEGYKPTR
CAHLHLEHLPADSLTLFDRGYPGHWLFALFAQQQRHFLMRLPCGYNAQVKAFLHSGQVEDTQLFVANHPEARLFCSEAGVDPASQIELRLIRVELANGES
EVLLTSLLDREAFPAEVFAELYHRRWGIETDFRRLKQTLTLDNFSGRSVTAVKQDFHAAQLLKNLALLMQHLLQPVIEQRHKGRKLRWKVNFTQGVSRLK
NTLVELLVRHCAQGLSNVLALMAKSLSAVRSGRSFARQRKRAASRGCEGYKPTR
Blast result :
Comments
ISPa1635 is 74% aa similar to ISHch2. ISPa1635 caused carbapenem resistance through insertional inactivation of the oprD gene from Pseudomonas aeruginosa. Multiple sequence alignments revealed a conserved DDE motif : D(N2)-69-D(N3)-110-E(C1).
References
1] De Palmenaer D, Siguier P, Mahillon J (2008) BMC Evol Biol , 8(1):18
2] Wolter,D.J., Hanson,N.D. and Lister,P.D.(2004)FEMS Microbiol. Lett. 236 (1), 137-143
2] Wolter,D.J., Hanson,N.D. and Lister,P.D.(2004)FEMS Microbiol. Lett. 236 (1), 137-143